Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex

Abstract G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorgani...

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Autores principales:	Lei He, Zhenyu Meng, Dechen Xu, Fangwei Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bee6b42f63743659c0f684867f5e2be
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spelling	oai:doaj.org-article:7bee6b42f63743659c0f684867f5e2be2021-12-02T15:08:25ZDual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex10.1038/s41598-017-19095-y2045-2322https://doaj.org/article/7bee6b42f63743659c0f684867f5e2be2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-19095-yhttps://doaj.org/toc/2045-2322Abstract G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorganic complexes via chelating principles, as a potent therapeutic strategy was surprisingly lack of exploration. Herein, a series of dinuclear platinum complexes, [(Pt(Dip)Cl)2(μ-diamine)](NO3)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), were designed to contain two dual-functional Pt cores connected by an alkyl linkage. Pt3 with nonanediamine linkage optimized the specific binding towards c-myc G-quadruplex via dual functional clamp on GQ as 1) non-covalently π-stacking of aromatic ligands, and 2) two Pt(II) cores covalently chelated to guanines at both 3′- and 5′-ends.Lei HeZhenyu MengDechen XuFangwei ShaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lei He Zhenyu Meng Dechen Xu Fangwei Shao Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
description	Abstract G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorganic complexes via chelating principles, as a potent therapeutic strategy was surprisingly lack of exploration. Herein, a series of dinuclear platinum complexes, [(Pt(Dip)Cl)2(μ-diamine)](NO3)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), were designed to contain two dual-functional Pt cores connected by an alkyl linkage. Pt3 with nonanediamine linkage optimized the specific binding towards c-myc G-quadruplex via dual functional clamp on GQ as 1) non-covalently π-stacking of aromatic ligands, and 2) two Pt(II) cores covalently chelated to guanines at both 3′- and 5′-ends.
format	article
author	Lei He Zhenyu Meng Dechen Xu Fangwei Shao
author_facet	Lei He Zhenyu Meng Dechen Xu Fangwei Shao
author_sort	Lei He
title	Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
title_short	Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
title_full	Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
title_fullStr	Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
title_full_unstemmed	Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
title_sort	dual functional dinuclear platinum complex with selective reactivity towards c-myc g-quadruplex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7bee6b42f63743659c0f684867f5e2be
work_keys_str_mv	AT leihe dualfunctionaldinuclearplatinumcomplexwithselectivereactivitytowardscmycgquadruplex AT zhenyumeng dualfunctionaldinuclearplatinumcomplexwithselectivereactivitytowardscmycgquadruplex AT dechenxu dualfunctionaldinuclearplatinumcomplexwithselectivereactivitytowardscmycgquadruplex AT fangweishao dualfunctionaldinuclearplatinumcomplexwithselectivereactivitytowardscmycgquadruplex
_version_	1718388129470087168

Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex

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