Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor

Xiang Li,1 Yun Gong,2,3 Xiaoqian Zhou,1 Hui Jin,1 Huanhuan Yan,1 Shige Wang,2 Jun Liu11Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People’s Republic of China; 2College of Science, University of Shanghai for Science and Technology...

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Autores principales:	Li X, Gong Y, Zhou X, Jin H, Yan H, Wang S, Liu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Soybean phospholipid MoS2 nanosheets in vivo photothermal regression breast tumor Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7bf188f3448945eaaae9a3003cdecc17
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spelling	oai:doaj.org-article:7bf188f3448945eaaae9a3003cdecc172021-12-02T04:28:15ZFacile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor1178-2013https://doaj.org/article/7bf188f3448945eaaae9a3003cdecc172016-04-01T00:00:00Zhttps://www.dovepress.com/facile-synthesis-of-soybean-phospholipid-encapsulated-mos2-nanosheets--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiang Li,1 Yun Gong,2,3 Xiaoqian Zhou,1 Hui Jin,1 Huanhuan Yan,1 Shige Wang,2 Jun Liu11Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People’s Republic of China; 2College of Science, University of Shanghai for Science and Technology, 3Shanghai Publishing and Printing College, Shanghai, People’s Republic of ChinaAbstract: Two-dimensional MoS2 nanosheet has been extensively explored as a photothermal agent for tumor regression; however, its surface modification remains a great challenge. Herein, as an alternative to surface polyethylene glycol modification (PEGylation), a facile approach based on “thin-film” strategy has been proposed for the first time to produce soybean phospholipid-encapsulated MoS2 (SP-MoS2) nanosheets. By simply vacuum-treating MoS2 nanosheets/soybean phospholipid/chloroform dispersion in a rotary evaporator, SP-MoS2 nanosheet was successfully constructed. Owing to the steric hindrance of polymer chains, the surface-coated soybean phospholipid endowed MoS2 nanosheets with excellent colloidal stability. Without showing detectable in vitro and in vivo hemolysis, coagulation, and cyto-/histotoxicity, the constructed SP-MoS2 nanosheets showed good photothermal conversion performance and photothermal stability. SP-MoS2 nanosheet was shown to be a promising platform for in vitro and in vivo breast tumor photothermal therapy. The produced SP-MoS2 nanosheets featured low cost, simple fabrication, and good in vivo hemo-/histocompatibility and hold promising potential for future clinical tumor therapy.Keywords: soybean phospholipid, MoS2 nanosheets, in vivo, photothermal regression, breast tumorLi XGong YZhou XJin HYan HWang SLiu JDove Medical PressarticleSoybean phospholipidMoS2 nanosheetsin vivophotothermal regressionbreast tumorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1819-1833 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Soybean phospholipid MoS2 nanosheets in vivo photothermal regression breast tumor Medicine (General) R5-920
spellingShingle	Soybean phospholipid MoS2 nanosheets in vivo photothermal regression breast tumor Medicine (General) R5-920 Li X Gong Y Zhou X Jin H Yan H Wang S Liu J Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor
description	Xiang Li,1 Yun Gong,2,3 Xiaoqian Zhou,1 Hui Jin,1 Huanhuan Yan,1 Shige Wang,2 Jun Liu11Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People’s Republic of China; 2College of Science, University of Shanghai for Science and Technology, 3Shanghai Publishing and Printing College, Shanghai, People’s Republic of ChinaAbstract: Two-dimensional MoS2 nanosheet has been extensively explored as a photothermal agent for tumor regression; however, its surface modification remains a great challenge. Herein, as an alternative to surface polyethylene glycol modification (PEGylation), a facile approach based on “thin-film” strategy has been proposed for the first time to produce soybean phospholipid-encapsulated MoS2 (SP-MoS2) nanosheets. By simply vacuum-treating MoS2 nanosheets/soybean phospholipid/chloroform dispersion in a rotary evaporator, SP-MoS2 nanosheet was successfully constructed. Owing to the steric hindrance of polymer chains, the surface-coated soybean phospholipid endowed MoS2 nanosheets with excellent colloidal stability. Without showing detectable in vitro and in vivo hemolysis, coagulation, and cyto-/histotoxicity, the constructed SP-MoS2 nanosheets showed good photothermal conversion performance and photothermal stability. SP-MoS2 nanosheet was shown to be a promising platform for in vitro and in vivo breast tumor photothermal therapy. The produced SP-MoS2 nanosheets featured low cost, simple fabrication, and good in vivo hemo-/histocompatibility and hold promising potential for future clinical tumor therapy.Keywords: soybean phospholipid, MoS2 nanosheets, in vivo, photothermal regression, breast tumor
format	article
author	Li X Gong Y Zhou X Jin H Yan H Wang S Liu J
author_facet	Li X Gong Y Zhou X Jin H Yan H Wang S Liu J
author_sort	Li X
title	Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor
title_short	Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor
title_full	Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor
title_fullStr	Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor
title_full_unstemmed	Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor
title_sort	facile synthesis of soybean phospholipid-encapsulated mos2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7bf188f3448945eaaae9a3003cdecc17
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_version_	1718401195155914752

Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor

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