Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and...

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Autores principales:	Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko, Aaron J. Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7bf1f249199b44a48e774d5c33748d09
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spelling	oai:doaj.org-article:7bf1f249199b44a48e774d5c33748d092021-12-02T17:31:27ZNon-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses10.1038/s41467-018-03037-x2041-1723https://doaj.org/article/7bf1f249199b44a48e774d5c33748d092018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03037-xhttps://doaj.org/toc/2041-1723Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma.Courtney S. MaloMatthew A. HugginsEmma N. GodderyHeather M. A. TolcherDanielle N. RennerFang JinMichael J. HansenLarry R. PeaseKevin D. PavelkoAaron J. JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Courtney S. Malo Matthew A. Huggins Emma N. Goddery Heather M. A. Tolcher Danielle N. Renner Fang Jin Michael J. Hansen Larry R. Pease Kevin D. Pavelko Aaron J. Johnson Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
description	Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma.
format	article
author	Courtney S. Malo Matthew A. Huggins Emma N. Goddery Heather M. A. Tolcher Danielle N. Renner Fang Jin Michael J. Hansen Larry R. Pease Kevin D. Pavelko Aaron J. Johnson
author_facet	Courtney S. Malo Matthew A. Huggins Emma N. Goddery Heather M. A. Tolcher Danielle N. Renner Fang Jin Michael J. Hansen Larry R. Pease Kevin D. Pavelko Aaron J. Johnson
author_sort	Courtney S. Malo
title	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_short	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_full	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_fullStr	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_full_unstemmed	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_sort	non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating cd8 + t cell responses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7bf1f249199b44a48e774d5c33748d09
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Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

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