The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia

Abstract This study investigated the outcomes and major adverse cardiovascular events (MACEs) incurred by acute myocardial infarction (AMI) patients comorbiding with hypertension and hyperhomocysteinemia (HHcy) during hospitalization and 1-year follow-up. 648 consecutive AMI patients were divided in...

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Autores principales:	Jumei Yan, Jiamin Zhou, Jun Huang, Hongyu Zhang, Zilin Deng, Yun Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bf62e239efe4bfcacd2c12102d39bb3
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spelling	oai:doaj.org-article:7bf62e239efe4bfcacd2c12102d39bb32021-11-28T12:17:11ZThe outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia10.1038/s41598-021-02340-w2045-2322https://doaj.org/article/7bf62e239efe4bfcacd2c12102d39bb32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02340-whttps://doaj.org/toc/2045-2322Abstract This study investigated the outcomes and major adverse cardiovascular events (MACEs) incurred by acute myocardial infarction (AMI) patients comorbiding with hypertension and hyperhomocysteinemia (HHcy) during hospitalization and 1-year follow-up. 648 consecutive AMI patients were divided into four categories: (1) hypertension with Hcy ≥ 15 µmol/L; (2) hypertension with Hcy < 15 µmol/L; (3) no-hypertension with Hcy ≥ 15 µmol/L; (4) no-hypertension with Hcy < 15 µmol/L. Information taken from these case files included gender, past medical history, vital signs, laboratory examination, electrocardiogram, coronary angiography, cardiac ultrasound, and medicine treatment. The primary endpoints were duration of coronary care units (CCU) stay, duration of in-hospital stay, and MACEs during follow-up. Our data show that hypertension and HHcy have a synergistic effect in AMI patients, AMI comorbiding with hypertension and HHcy patients had more severe multi-coronary artery disease and more frequent non-culprit coronary lesions complete clogging, had a higher prevalence of pro-brain natriuretic peptide, and significant decreases in the left ventricular ejection fraction. These patients had significant increases in the duration of CCU stay and in-hospital stay, had significant increase in the rate of MACEs, had significant decreases in the survival rate during follow-up.Jumei YanJiamin ZhouJun HuangHongyu ZhangZilin DengYun DuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jumei Yan Jiamin Zhou Jun Huang Hongyu Zhang Zilin Deng Yun Du The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia
description	Abstract This study investigated the outcomes and major adverse cardiovascular events (MACEs) incurred by acute myocardial infarction (AMI) patients comorbiding with hypertension and hyperhomocysteinemia (HHcy) during hospitalization and 1-year follow-up. 648 consecutive AMI patients were divided into four categories: (1) hypertension with Hcy ≥ 15 µmol/L; (2) hypertension with Hcy < 15 µmol/L; (3) no-hypertension with Hcy ≥ 15 µmol/L; (4) no-hypertension with Hcy < 15 µmol/L. Information taken from these case files included gender, past medical history, vital signs, laboratory examination, electrocardiogram, coronary angiography, cardiac ultrasound, and medicine treatment. The primary endpoints were duration of coronary care units (CCU) stay, duration of in-hospital stay, and MACEs during follow-up. Our data show that hypertension and HHcy have a synergistic effect in AMI patients, AMI comorbiding with hypertension and HHcy patients had more severe multi-coronary artery disease and more frequent non-culprit coronary lesions complete clogging, had a higher prevalence of pro-brain natriuretic peptide, and significant decreases in the left ventricular ejection fraction. These patients had significant increases in the duration of CCU stay and in-hospital stay, had significant increase in the rate of MACEs, had significant decreases in the survival rate during follow-up.
format	article
author	Jumei Yan Jiamin Zhou Jun Huang Hongyu Zhang Zilin Deng Yun Du
author_facet	Jumei Yan Jiamin Zhou Jun Huang Hongyu Zhang Zilin Deng Yun Du
author_sort	Jumei Yan
title	The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia
title_short	The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia
title_full	The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia
title_fullStr	The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia
title_full_unstemmed	The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia
title_sort	outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bf62e239efe4bfcacd2c12102d39bb3
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The outcomes of acute myocardial infarction patients comorbidity with hypertension and hyperhomocysteinemia

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