Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma is the second most common skin cancer in the United States. Currently, there is no standardized management approach for patients with cutaneous squamous cell carcinoma who develop metastatic or locally advanced disease and are not candidates for curative surgery or...

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Autores principales:	Guilherme Rabinowits, Michael R. Migden, Todd E. Schlesinger, Robert L. Ferris, Morganna Freeman, Valerie Guild, Shlomo Koyfman, Anna C. Pavlick, Neil Swanson, Gregory T. Wolf, Scott M. Dinehart
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/7bfa396119cd430f85368f3066722ea1
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spelling	oai:doaj.org-article:7bfa396119cd430f85368f3066722ea12021-11-04T04:44:00ZEvidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma2667-026710.1016/j.xjidi.2021.100045https://doaj.org/article/7bfa396119cd430f85368f3066722ea12021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667026721000461https://doaj.org/toc/2667-0267Cutaneous squamous cell carcinoma is the second most common skin cancer in the United States. Currently, there is no standardized management approach for patients with cutaneous squamous cell carcinoma who develop metastatic or locally advanced disease and are not candidates for curative surgery or curative radiation. To address this issue, the Expert Cutaneous Squamous Cell Carcinoma Leadership program convened an expert steering committee to develop evidence-based consensus recommendations on the basis of a large, structured literature review. Consensus was achieved through modified Delphi methodology. The steering committee included five dermatologists, three medical oncologists, two head and neck surgeons, one radiation oncologist, and a patient advocacy group representative. The steering committee aligned on the following clinical topics: diagnosis and identification of patients considered not candidates for surgery; staging systems and risk stratification in cutaneous squamous cell carcinoma; the role of radiation therapy, surgery, and systemic therapy in the management of advanced disease, with a focus on immunotherapy; referral patterns; survivorship care; and inclusion of the patient’s perspective. Consensus was achieved on 34 recommendations addressing 12 key clinical questions. The Expert Cutaneous Squamous Cell Carcinoma Leadership steering committee’s evidence-based consensus recommendations may provide healthcare professionals with practically oriented guidance to help optimize outcomes for patients with advanced cutaneous squamous cell carcinoma.Guilherme RabinowitsMichael R. MigdenTodd E. SchlesingerRobert L. FerrisMorganna FreemanValerie GuildShlomo KoyfmanAnna C. PavlickNeil SwansonGregory T. WolfScott M. DinehartElsevierarticleDermatologyRL1-803ENJID Innovations, Vol 1, Iss 4, Pp 100045- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Guilherme Rabinowits Michael R. Migden Todd E. Schlesinger Robert L. Ferris Morganna Freeman Valerie Guild Shlomo Koyfman Anna C. Pavlick Neil Swanson Gregory T. Wolf Scott M. Dinehart Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma
description	Cutaneous squamous cell carcinoma is the second most common skin cancer in the United States. Currently, there is no standardized management approach for patients with cutaneous squamous cell carcinoma who develop metastatic or locally advanced disease and are not candidates for curative surgery or curative radiation. To address this issue, the Expert Cutaneous Squamous Cell Carcinoma Leadership program convened an expert steering committee to develop evidence-based consensus recommendations on the basis of a large, structured literature review. Consensus was achieved through modified Delphi methodology. The steering committee included five dermatologists, three medical oncologists, two head and neck surgeons, one radiation oncologist, and a patient advocacy group representative. The steering committee aligned on the following clinical topics: diagnosis and identification of patients considered not candidates for surgery; staging systems and risk stratification in cutaneous squamous cell carcinoma; the role of radiation therapy, surgery, and systemic therapy in the management of advanced disease, with a focus on immunotherapy; referral patterns; survivorship care; and inclusion of the patient’s perspective. Consensus was achieved on 34 recommendations addressing 12 key clinical questions. The Expert Cutaneous Squamous Cell Carcinoma Leadership steering committee’s evidence-based consensus recommendations may provide healthcare professionals with practically oriented guidance to help optimize outcomes for patients with advanced cutaneous squamous cell carcinoma.
format	article
author	Guilherme Rabinowits Michael R. Migden Todd E. Schlesinger Robert L. Ferris Morganna Freeman Valerie Guild Shlomo Koyfman Anna C. Pavlick Neil Swanson Gregory T. Wolf Scott M. Dinehart
author_facet	Guilherme Rabinowits Michael R. Migden Todd E. Schlesinger Robert L. Ferris Morganna Freeman Valerie Guild Shlomo Koyfman Anna C. Pavlick Neil Swanson Gregory T. Wolf Scott M. Dinehart
author_sort	Guilherme Rabinowits
title	Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma
title_short	Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma
title_full	Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma
title_fullStr	Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma
title_full_unstemmed	Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma
title_sort	evidence-based consensus recommendations for the evolving treatment of patients with high-risk and advanced cutaneous squamous cell carcinoma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7bfa396119cd430f85368f3066722ea1
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Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma

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