Gastric Helicobacter suis Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model

The exact etiology of Parkinson’s disease (PD) remains largely unknown, but more and more research suggests the involvement of the gut microbiota. Interestingly, idiopathic PD patients were shown to have at least a 10 times higher prevalence of Helicobacter suis (H. suis&...

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Autores principales:	Helena Berlamont, Arnout Bruggeman, Eva Bauwens, Charysse Vandendriessche, Elien Clarebout, Junhua Xie, Sofie De Bruyckere, Griet Van Imschoot, Elien Van Wonterghem, Richard Ducatelle, Patrick Santens, Annemieke Smet, Freddy Haesebrouck, Roosmarijn E. Vandenbroucke
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Parkinson’s disease gut–brain axis oxidative stress <i>Helicobacter</i> 6-OHDA Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7bfab95dcd3448a2b9af833da32f0df5
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spelling	oai:doaj.org-article:7bfab95dcd3448a2b9af833da32f0df52021-11-11T16:49:01ZGastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model10.3390/ijms2221113281422-00671661-6596https://doaj.org/article/7bfab95dcd3448a2b9af833da32f0df52021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11328https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The exact etiology of Parkinson’s disease (PD) remains largely unknown, but more and more research suggests the involvement of the gut microbiota. Interestingly, idiopathic PD patients were shown to have at least a 10 times higher prevalence of <i>Helicobacter suis</i> (<i>H. suis</i>) DNA in gastric biopsies compared to control patients. <i>H. suis</i> is a zoonotic <i>Helicobacter</i> species that naturally colonizes the stomach of pigs and non-human primates but can be transmitted to humans. Here, we investigated the influence of a gastric <i>H. suis</i> infection on PD disease progression through a 6-hydroxydopamine (6-OHDA) mouse model. Therefore, mice with either a short- or long-term <i>H. suis</i> infection were stereotactically injected with 6-OHDA in the left striatum and sampled one week later. Remarkably, a reduced loss of dopaminergic neurons was seen in the <i>H. suis/</i>6-OHDA groups compared to the control/6-OHDA groups. Correspondingly, motor function of the <i>H. suis</i>-infected 6-OHDA mice was superior to that in the non-infected 6-OHDA mice. Interestingly, we also observed higher expression levels of antioxidant genes in brain tissue from <i>H. suis</i>-infected 6-OHDA mice, as a potential explanation for the reduced 6-OHDA-induced cell loss. Our data support an unexpected neuroprotective effect of gastric <i>H. suis</i> on PD pathology, mediated through changes in oxidative stress.Helena BerlamontArnout BruggemanEva BauwensCharysse VandendriesscheElien ClareboutJunhua XieSofie De BruyckereGriet Van ImschootElien Van WonterghemRichard DucatellePatrick SantensAnnemieke SmetFreddy HaesebrouckRoosmarijn E. VandenbrouckeMDPI AGarticleParkinson’s diseasegut–brain axisoxidative stress<i>Helicobacter</i>6-OHDABiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11328, p 11328 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease gut–brain axis oxidative stress <i>Helicobacter</i> 6-OHDA Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Parkinson’s disease gut–brain axis oxidative stress <i>Helicobacter</i> 6-OHDA Biology (General) QH301-705.5 Chemistry QD1-999 Helena Berlamont Arnout Bruggeman Eva Bauwens Charysse Vandendriessche Elien Clarebout Junhua Xie Sofie De Bruyckere Griet Van Imschoot Elien Van Wonterghem Richard Ducatelle Patrick Santens Annemieke Smet Freddy Haesebrouck Roosmarijn E. Vandenbroucke Gastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model
description	The exact etiology of Parkinson’s disease (PD) remains largely unknown, but more and more research suggests the involvement of the gut microbiota. Interestingly, idiopathic PD patients were shown to have at least a 10 times higher prevalence of <i>Helicobacter suis</i> (<i>H. suis</i>) DNA in gastric biopsies compared to control patients. <i>H. suis</i> is a zoonotic <i>Helicobacter</i> species that naturally colonizes the stomach of pigs and non-human primates but can be transmitted to humans. Here, we investigated the influence of a gastric <i>H. suis</i> infection on PD disease progression through a 6-hydroxydopamine (6-OHDA) mouse model. Therefore, mice with either a short- or long-term <i>H. suis</i> infection were stereotactically injected with 6-OHDA in the left striatum and sampled one week later. Remarkably, a reduced loss of dopaminergic neurons was seen in the <i>H. suis/</i>6-OHDA groups compared to the control/6-OHDA groups. Correspondingly, motor function of the <i>H. suis</i>-infected 6-OHDA mice was superior to that in the non-infected 6-OHDA mice. Interestingly, we also observed higher expression levels of antioxidant genes in brain tissue from <i>H. suis</i>-infected 6-OHDA mice, as a potential explanation for the reduced 6-OHDA-induced cell loss. Our data support an unexpected neuroprotective effect of gastric <i>H. suis</i> on PD pathology, mediated through changes in oxidative stress.
format	article
author	Helena Berlamont Arnout Bruggeman Eva Bauwens Charysse Vandendriessche Elien Clarebout Junhua Xie Sofie De Bruyckere Griet Van Imschoot Elien Van Wonterghem Richard Ducatelle Patrick Santens Annemieke Smet Freddy Haesebrouck Roosmarijn E. Vandenbroucke
author_facet	Helena Berlamont Arnout Bruggeman Eva Bauwens Charysse Vandendriessche Elien Clarebout Junhua Xie Sofie De Bruyckere Griet Van Imschoot Elien Van Wonterghem Richard Ducatelle Patrick Santens Annemieke Smet Freddy Haesebrouck Roosmarijn E. Vandenbroucke
author_sort	Helena Berlamont
title	Gastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model
title_short	Gastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model
title_full	Gastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model
title_fullStr	Gastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model
title_full_unstemmed	Gastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model
title_sort	gastric <i>helicobacter suis</i> infection partially protects against neurotoxicity in a 6-ohda parkinson’s disease mouse model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7bfab95dcd3448a2b9af833da32f0df5
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Gastric <i>Helicobacter suis</i> Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model

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