Defining a therapeutic range for regeneration of ischemic myocardium via shock waves

Abstract Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a...

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Autores principales:	Leo Pölzl, Felix Nägele, Jakob Hirsch, Michael Graber, Daniela Lobenwein, Elke Kirchmair, Rosalie Huber, Christian Dorfmüller, Sophia Lechner, Georg Schäfer, Martin Hermann, Helga Fritsch, Ivan Tancevski, Michael Grimm, Johannes Holfeld, Can Gollmann-Tepeköylü
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bfadef780a5486098fb307e1dee3155
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spelling	oai:doaj.org-article:7bfadef780a5486098fb307e1dee31552021-12-02T15:23:04ZDefining a therapeutic range for regeneration of ischemic myocardium via shock waves10.1038/s41598-020-79776-z2045-2322https://doaj.org/article/7bfadef780a5486098fb307e1dee31552021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79776-zhttps://doaj.org/toc/2045-2322Abstract Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a therapeutic range for shock wave application for myocardial regeneration. We could demonstrate that SWT does not induce cellular damage beneath energy levels of 0.27 mJ/mm2 total flux density. Endothelial cell proliferation, angiogenic gene expression and phosphorylation of AKT and ERK are enhanced in a dose dependent manner until 0.15 mJ/mm2 energy flux density. SWT induces regeneration of ischemic muscle in vivo via expression of angiogenic gene expression, enhanced neovascularization and improved limb perfusion in a dose-dependent manner. Therefore, we provide evidence for a dose-dependent induction of angiogenesis after SWT, as well as the absence of cellular damage upon SWT within the therapeutic range. These data define for the first time a therapeutic range of SWT, a promising regenerative treatment option for ischemic cardiomyopathy.Leo PölzlFelix NägeleJakob HirschMichael GraberDaniela LobenweinElke KirchmairRosalie HuberChristian DorfmüllerSophia LechnerGeorg SchäferMartin HermannHelga FritschIvan TancevskiMichael GrimmJohannes HolfeldCan Gollmann-TepeköylüNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leo Pölzl Felix Nägele Jakob Hirsch Michael Graber Daniela Lobenwein Elke Kirchmair Rosalie Huber Christian Dorfmüller Sophia Lechner Georg Schäfer Martin Hermann Helga Fritsch Ivan Tancevski Michael Grimm Johannes Holfeld Can Gollmann-Tepeköylü Defining a therapeutic range for regeneration of ischemic myocardium via shock waves
description	Abstract Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a therapeutic range for shock wave application for myocardial regeneration. We could demonstrate that SWT does not induce cellular damage beneath energy levels of 0.27 mJ/mm2 total flux density. Endothelial cell proliferation, angiogenic gene expression and phosphorylation of AKT and ERK are enhanced in a dose dependent manner until 0.15 mJ/mm2 energy flux density. SWT induces regeneration of ischemic muscle in vivo via expression of angiogenic gene expression, enhanced neovascularization and improved limb perfusion in a dose-dependent manner. Therefore, we provide evidence for a dose-dependent induction of angiogenesis after SWT, as well as the absence of cellular damage upon SWT within the therapeutic range. These data define for the first time a therapeutic range of SWT, a promising regenerative treatment option for ischemic cardiomyopathy.
format	article
author	Leo Pölzl Felix Nägele Jakob Hirsch Michael Graber Daniela Lobenwein Elke Kirchmair Rosalie Huber Christian Dorfmüller Sophia Lechner Georg Schäfer Martin Hermann Helga Fritsch Ivan Tancevski Michael Grimm Johannes Holfeld Can Gollmann-Tepeköylü
author_facet	Leo Pölzl Felix Nägele Jakob Hirsch Michael Graber Daniela Lobenwein Elke Kirchmair Rosalie Huber Christian Dorfmüller Sophia Lechner Georg Schäfer Martin Hermann Helga Fritsch Ivan Tancevski Michael Grimm Johannes Holfeld Can Gollmann-Tepeköylü
author_sort	Leo Pölzl
title	Defining a therapeutic range for regeneration of ischemic myocardium via shock waves
title_short	Defining a therapeutic range for regeneration of ischemic myocardium via shock waves
title_full	Defining a therapeutic range for regeneration of ischemic myocardium via shock waves
title_fullStr	Defining a therapeutic range for regeneration of ischemic myocardium via shock waves
title_full_unstemmed	Defining a therapeutic range for regeneration of ischemic myocardium via shock waves
title_sort	defining a therapeutic range for regeneration of ischemic myocardium via shock waves
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bfadef780a5486098fb307e1dee3155
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Defining a therapeutic range for regeneration of ischemic myocardium via shock waves

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