Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy

Yadong Xing, Luoyuan Li, Xicheng Ai, Limin Fu Department of Chemistry, Renmin University of China, Beijing, People’s Republic of China Abstract: In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs)....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xing YD, Li LY, Ai XC, Fu LM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	upconversion nanoparticles polyaniline UCL photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7bfb226b5dd447f58aae570c7b27b106
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7bfb226b5dd447f58aae570c7b27b106
record_format	dspace
spelling	oai:doaj.org-article:7bfb226b5dd447f58aae570c7b27b1062021-12-02T01:04:57ZPolyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy1178-2013https://doaj.org/article/7bfb226b5dd447f58aae570c7b27b1062016-09-01T00:00:00Zhttps://www.dovepress.com/polyaniline-coated-upconversion-nanoparticles-with-upconverting-lumine-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yadong Xing, Luoyuan Li, Xicheng Ai, Limin Fu Department of Chemistry, Renmin University of China, Beijing, People’s Republic of China Abstract: In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 µg mL-1). Blood analysis and histological experiments demonstrated that the UCNPs-PANPs exhibited no apparent toxicity in mice in vivo. Besides their efficacy in photothermal cancer cell ablation, the UCNP-PANP nanosystem was found to achieve an effective in vivo tumor ablation effect after irradiation using an 808 nm laser. These results demonstrate the potential of the hybrid nanocomposites for use in imaging-guided photothermal therapy. Keywords: upconversion nanoparticles, polyaniline, upconversion luminescence, photothermal therapyXing YDLi LYAi XCFu LMDove Medical Pressarticleupconversion nanoparticlespolyanilineUCLphotothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4327-4338 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	upconversion nanoparticles polyaniline UCL photothermal therapy Medicine (General) R5-920
spellingShingle	upconversion nanoparticles polyaniline UCL photothermal therapy Medicine (General) R5-920 Xing YD Li LY Ai XC Fu LM Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
description	Yadong Xing, Luoyuan Li, Xicheng Ai, Limin Fu Department of Chemistry, Renmin University of China, Beijing, People’s Republic of China Abstract: In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 µg mL-1). Blood analysis and histological experiments demonstrated that the UCNPs-PANPs exhibited no apparent toxicity in mice in vivo. Besides their efficacy in photothermal cancer cell ablation, the UCNP-PANP nanosystem was found to achieve an effective in vivo tumor ablation effect after irradiation using an 808 nm laser. These results demonstrate the potential of the hybrid nanocomposites for use in imaging-guided photothermal therapy. Keywords: upconversion nanoparticles, polyaniline, upconversion luminescence, photothermal therapy
format	article
author	Xing YD Li LY Ai XC Fu LM
author_facet	Xing YD Li LY Ai XC Fu LM
author_sort	Xing YD
title	Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
title_short	Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
title_full	Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
title_fullStr	Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
title_full_unstemmed	Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
title_sort	polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7bfb226b5dd447f58aae570c7b27b106
work_keys_str_mv	AT xingyd polyanilinecoatedupconversionnanoparticleswithupconvertingluminescentandphotothermalconversionpropertiesforphotothermalcancertherapy AT lily polyanilinecoatedupconversionnanoparticleswithupconvertingluminescentandphotothermalconversionpropertiesforphotothermalcancertherapy AT aixc polyanilinecoatedupconversionnanoparticleswithupconvertingluminescentandphotothermalconversionpropertiesforphotothermalcancertherapy AT fulm polyanilinecoatedupconversionnanoparticleswithupconvertingluminescentandphotothermalconversionpropertiesforphotothermalcancertherapy
_version_	1718403324439429120

Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy

Ejemplares similares