Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival

Gastric cancer: Chromosome rearrangement linked to less aggressive tumors Gastric tumors often harbor a chromosome abnormality that disrupts a key signaling gene, resulting in less aggressive cancers. Oi Lian Kon from the National Cancer Centre Singapore and colleagues searched for chromosomal rearr...

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Autores principales:	Siew Hong Leong, Kyaw Myo Lwin, Sze Sing Lee, Wai Har Ng, Kia Min Ng, Soo Yong Tan, Bee Ling Ng, Nigel P. Carter, Carol Tang, Oi Lian Kon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7bfd55e1ad994240a600d74fa922acd5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:7bfd55e1ad994240a600d74fa922acd52021-12-02T16:05:43ZChromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival10.1038/s41698-017-0012-32397-768Xhttps://doaj.org/article/7bfd55e1ad994240a600d74fa922acd52017-05-01T00:00:00Zhttps://doi.org/10.1038/s41698-017-0012-3https://doaj.org/toc/2397-768XGastric cancer: Chromosome rearrangement linked to less aggressive tumors Gastric tumors often harbor a chromosome abnormality that disrupts a key signaling gene, resulting in less aggressive cancers. Oi Lian Kon from the National Cancer Centre Singapore and colleagues searched for chromosomal rearrangements in 17 gastric cancer cell lines. The researchers discovered a recurrent breakpoint in six of the cell lines that mapped to a gene called DOK6, which encodes a protein that provides a docking platform for multiple signaling molecules. They also found the abnormality in 22 of 99 tissue samples taken from gastric cancer patients. This defect led to lower expression of DOK6 and, in turn, less active oncogenic signaling pathways. Patients with low DOK6-expressing gastric cancers lived longer on average than those with high DOK6-expressing tumors. The findings point to DOK6 levels as a potential drug target and diagnostic biomarker.Siew Hong LeongKyaw Myo LwinSze Sing LeeWai Har NgKia Min NgSoo Yong TanBee Ling NgNigel P. CarterCarol TangOi Lian KonNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 1, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Siew Hong Leong Kyaw Myo Lwin Sze Sing Lee Wai Har Ng Kia Min Ng Soo Yong Tan Bee Ling Ng Nigel P. Carter Carol Tang Oi Lian Kon Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival
description	Gastric cancer: Chromosome rearrangement linked to less aggressive tumors Gastric tumors often harbor a chromosome abnormality that disrupts a key signaling gene, resulting in less aggressive cancers. Oi Lian Kon from the National Cancer Centre Singapore and colleagues searched for chromosomal rearrangements in 17 gastric cancer cell lines. The researchers discovered a recurrent breakpoint in six of the cell lines that mapped to a gene called DOK6, which encodes a protein that provides a docking platform for multiple signaling molecules. They also found the abnormality in 22 of 99 tissue samples taken from gastric cancer patients. This defect led to lower expression of DOK6 and, in turn, less active oncogenic signaling pathways. Patients with low DOK6-expressing gastric cancers lived longer on average than those with high DOK6-expressing tumors. The findings point to DOK6 levels as a potential drug target and diagnostic biomarker.
format	article
author	Siew Hong Leong Kyaw Myo Lwin Sze Sing Lee Wai Har Ng Kia Min Ng Soo Yong Tan Bee Ling Ng Nigel P. Carter Carol Tang Oi Lian Kon
author_facet	Siew Hong Leong Kyaw Myo Lwin Sze Sing Lee Wai Har Ng Kia Min Ng Soo Yong Tan Bee Ling Ng Nigel P. Carter Carol Tang Oi Lian Kon
author_sort	Siew Hong Leong
title	Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival
title_short	Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival
title_full	Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival
title_fullStr	Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival
title_full_unstemmed	Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival
title_sort	chromosomal breaks at fra18c: association with reduced dok6 expression, altered oncogenic signaling and increased gastric cancer survival
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7bfd55e1ad994240a600d74fa922acd5
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Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival

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