The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease

Brain-derived neurotrophic factor (BDNF) is involved in the survival and maturation of neurons, and also promotes and controls neurogenesis. Its levels are lowered in many neurodegenerative diseases, including Huntington’s disease (HD). Clinical pictures of HD can be very diverse, which makes it dif...

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Autores principales:	Klaudia Plinta, Andrzej Plewka, Krzysztof Pawlicki, Nikola Zmarzły, Magdalena Wójcik-Pędziwiatr, Marcin Rudziński, Agnieszka Krzak-Kubica, Magdalena Doręgowska-Stachera, Monika Rudzińska-Bar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Huntington’s disease BDNF disease severity Medicine R
Acceso en línea:	https://doaj.org/article/7bfdf36775e343d89f60986ef93c4073
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spelling	oai:doaj.org-article:7bfdf36775e343d89f60986ef93c40732021-11-11T17:47:23ZThe Utility of BDNF Detection in Assessing Severity of Huntington’s Disease10.3390/jcm102151812077-0383https://doaj.org/article/7bfdf36775e343d89f60986ef93c40732021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5181https://doaj.org/toc/2077-0383Brain-derived neurotrophic factor (BDNF) is involved in the survival and maturation of neurons, and also promotes and controls neurogenesis. Its levels are lowered in many neurodegenerative diseases, including Huntington’s disease (HD). Clinical pictures of HD can be very diverse, which makes it difficult to assess its severity; however, molecular markers may be helpful. The aim of the study was to determine the relationship between HD severity and the plasma BDNF concentration in HD patients. The study recruited 42 patients with diagnosed and genetically confirmed HD and 40 healthy volunteers. BDNF levels were determined in plasma with the enzyme-linked immunosorbent assay (ELISA). Correlations between BDNF levels and clinical profiles and HD severity were also investigated. The BDNF level was significantly lower in HD patients compared to the control. There was no correlation between the BDNF level and motor symptoms and cognitive impairment. In the early disease stages, BDNF levels were associated with a better neurological examination, independence, and functional evaluation, in contrast to later HD stages, where the correlations were inverse. Multidirectional correlations between parameters of saccadic disorders and the BDNF level do not allow for drawing a conclusion, whether or not there is a relationship between the severity of saccadic disorders and the BDNF concentration.Klaudia PlintaAndrzej PlewkaKrzysztof PawlickiNikola ZmarzłyMagdalena Wójcik-PędziwiatrMarcin RudzińskiAgnieszka Krzak-KubicaMagdalena Doręgowska-StacheraMonika Rudzińska-BarMDPI AGarticleHuntington’s diseaseBDNFdisease severityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5181, p 5181 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Huntington’s disease BDNF disease severity Medicine R
spellingShingle	Huntington’s disease BDNF disease severity Medicine R Klaudia Plinta Andrzej Plewka Krzysztof Pawlicki Nikola Zmarzły Magdalena Wójcik-Pędziwiatr Marcin Rudziński Agnieszka Krzak-Kubica Magdalena Doręgowska-Stachera Monika Rudzińska-Bar The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
description	Brain-derived neurotrophic factor (BDNF) is involved in the survival and maturation of neurons, and also promotes and controls neurogenesis. Its levels are lowered in many neurodegenerative diseases, including Huntington’s disease (HD). Clinical pictures of HD can be very diverse, which makes it difficult to assess its severity; however, molecular markers may be helpful. The aim of the study was to determine the relationship between HD severity and the plasma BDNF concentration in HD patients. The study recruited 42 patients with diagnosed and genetically confirmed HD and 40 healthy volunteers. BDNF levels were determined in plasma with the enzyme-linked immunosorbent assay (ELISA). Correlations between BDNF levels and clinical profiles and HD severity were also investigated. The BDNF level was significantly lower in HD patients compared to the control. There was no correlation between the BDNF level and motor symptoms and cognitive impairment. In the early disease stages, BDNF levels were associated with a better neurological examination, independence, and functional evaluation, in contrast to later HD stages, where the correlations were inverse. Multidirectional correlations between parameters of saccadic disorders and the BDNF level do not allow for drawing a conclusion, whether or not there is a relationship between the severity of saccadic disorders and the BDNF concentration.
format	article
author	Klaudia Plinta Andrzej Plewka Krzysztof Pawlicki Nikola Zmarzły Magdalena Wójcik-Pędziwiatr Marcin Rudziński Agnieszka Krzak-Kubica Magdalena Doręgowska-Stachera Monika Rudzińska-Bar
author_facet	Klaudia Plinta Andrzej Plewka Krzysztof Pawlicki Nikola Zmarzły Magdalena Wójcik-Pędziwiatr Marcin Rudziński Agnieszka Krzak-Kubica Magdalena Doręgowska-Stachera Monika Rudzińska-Bar
author_sort	Klaudia Plinta
title	The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
title_short	The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
title_full	The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
title_fullStr	The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
title_full_unstemmed	The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
title_sort	utility of bdnf detection in assessing severity of huntington’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7bfdf36775e343d89f60986ef93c4073
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The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease

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