Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study

Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study

Edsel B. Ing,1,2 Royce Ing,2 Xinyang Liu,3 Angela Zhang,1 Nurhan Torun,4 Michael Sey,5 Christian Pagnoux6 1Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, 2Toronto Eyelid Strabismus & Orbit Surgery Clinic, Toronto, ON, Canada; 3Department of Medicine, Internal Medicin...

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Autores principales: Ing EB, Ing R, Liu X, Zhang A, Torun N, Sey M, Pagnoux C
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
epidemiology
shingles
temporal arteritis
immunopathogenesis
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/7c01a7c52a5c493db9355928f04f5141
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spelling oai:doaj.org-article:7c01a7c52a5c493db9355928f04f51412021-12-02T04:43:51ZDoes herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study1177-5483https://doaj.org/article/7c01a7c52a5c493db9355928f04f51412018-01-01T00:00:00Zhttps://www.dovepress.com/does-herpes-zoster-predispose-to-giant-cell-arteritis-a-geo-epidemiolo-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Edsel B. Ing,1,2 Royce Ing,2 Xinyang Liu,3 Angela Zhang,1 Nurhan Torun,4 Michael Sey,5 Christian Pagnoux6 1Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, 2Toronto Eyelid Strabismus & Orbit Surgery Clinic, Toronto, ON, Canada; 3Department of Medicine, Internal Medicine, Fudan University, Shanghai, China; 4Ophthalmology, Harvard Medical School, Boston, MA, USA; 5Department of Medicine, Western University Schulich School of Medicine, London, ON, 6Vasculitis Clinic, Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly and can cause irreversible blindness and aortitis. Varicella zoster (VZ), which is potentially preventable by vaccination, has been proposed as a possible immune trigger for GCA, but this is controversial. The incidence of GCA varies widely by country. If VZ virus contributes to the immunopathogenesis of GCA we hypothesized that nations with increased incidence of GCA would also have increased incidence of herpes zoster (HZ). We conducted an ecologic analysis to determine the relationship between the incidence of HZ and GCA in different countries.Methods: A literature search for the incidence rates (IRs) of GCA and HZ from different countries was conducted. Correlation and linear regression was performed comparing the disease IR of each country for subjects 50 years of age or older.Results: We found the IR for GCA and HZ from 14 countries. Comparing the IRs for GCA and HZ in 50-year-olds, the Pearson product-moment correlation (r) was -0.51, with linear regression coefficient (β) -2.92 (95% CI -5.41, -0.43; p=0.025) using robust standard errors. Comparing the IRs for GCA and HZ in 70-year-olds, r was -0.40, with β -1.78, which was not statistically significant (95% CI -4.10, 0.53; p=0.12).Conclusion: Although this geo-epidemiologic study has potential for aggregation and selection biases, there was no positive biologic gradient between the incidence of clinically evident HZ and GCA. Keywords: epidemiology, shingles, temporal arteritis, immunopathogenesisIng EBIng RLiu XZhang ATorun NSey MPagnoux CDove Medical Pressarticleepidemiologyshinglestemporal arteritisimmunopathogenesisOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 113-118 (2018)
institution DOAJ
collection DOAJ
language EN
topic epidemiology
shingles
temporal arteritis
immunopathogenesis
Ophthalmology
RE1-994
spellingShingle epidemiology
shingles
temporal arteritis
immunopathogenesis
Ophthalmology
RE1-994
Ing EB
Ing R
Liu X
Zhang A
Torun N
Sey M
Pagnoux C
Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
description Edsel B. Ing,1,2 Royce Ing,2 Xinyang Liu,3 Angela Zhang,1 Nurhan Torun,4 Michael Sey,5 Christian Pagnoux6 1Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, 2Toronto Eyelid Strabismus & Orbit Surgery Clinic, Toronto, ON, Canada; 3Department of Medicine, Internal Medicine, Fudan University, Shanghai, China; 4Ophthalmology, Harvard Medical School, Boston, MA, USA; 5Department of Medicine, Western University Schulich School of Medicine, London, ON, 6Vasculitis Clinic, Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly and can cause irreversible blindness and aortitis. Varicella zoster (VZ), which is potentially preventable by vaccination, has been proposed as a possible immune trigger for GCA, but this is controversial. The incidence of GCA varies widely by country. If VZ virus contributes to the immunopathogenesis of GCA we hypothesized that nations with increased incidence of GCA would also have increased incidence of herpes zoster (HZ). We conducted an ecologic analysis to determine the relationship between the incidence of HZ and GCA in different countries.Methods: A literature search for the incidence rates (IRs) of GCA and HZ from different countries was conducted. Correlation and linear regression was performed comparing the disease IR of each country for subjects 50 years of age or older.Results: We found the IR for GCA and HZ from 14 countries. Comparing the IRs for GCA and HZ in 50-year-olds, the Pearson product-moment correlation (r) was -0.51, with linear regression coefficient (β) -2.92 (95% CI -5.41, -0.43; p=0.025) using robust standard errors. Comparing the IRs for GCA and HZ in 70-year-olds, r was -0.40, with β -1.78, which was not statistically significant (95% CI -4.10, 0.53; p=0.12).Conclusion: Although this geo-epidemiologic study has potential for aggregation and selection biases, there was no positive biologic gradient between the incidence of clinically evident HZ and GCA. Keywords: epidemiology, shingles, temporal arteritis, immunopathogenesis
format article
author Ing EB
Ing R
Liu X
Zhang A
Torun N
Sey M
Pagnoux C
author_facet Ing EB
Ing R
Liu X
Zhang A
Torun N
Sey M
Pagnoux C
author_sort Ing EB
title Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
title_short Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
title_full Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
title_fullStr Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
title_full_unstemmed Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
title_sort does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/7c01a7c52a5c493db9355928f04f5141
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