Advanced mycelium materials as potential self-growing biomedical scaffolds

Abstract Mycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physi...

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Autores principales:	Maria Elena Antinori, Marco Contardi, Giulia Suarato, Andrea Armirotti, Rosalia Bertorelli, Giorgio Mancini, Doriana Debellis, Athanassia Athanassiou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c024dc1765d4958997b3389a94e425e
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spelling	oai:doaj.org-article:7c024dc1765d4958997b3389a94e425e2021-12-02T17:41:32ZAdvanced mycelium materials as potential self-growing biomedical scaffolds10.1038/s41598-021-91572-x2045-2322https://doaj.org/article/7c024dc1765d4958997b3389a94e425e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91572-xhttps://doaj.org/toc/2045-2322Abstract Mycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.Maria Elena AntinoriMarco ContardiGiulia SuaratoAndrea ArmirottiRosalia BertorelliGiorgio ManciniDoriana DebellisAthanassia AthanassiouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Elena Antinori Marco Contardi Giulia Suarato Andrea Armirotti Rosalia Bertorelli Giorgio Mancini Doriana Debellis Athanassia Athanassiou Advanced mycelium materials as potential self-growing biomedical scaffolds
description	Abstract Mycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.
format	article
author	Maria Elena Antinori Marco Contardi Giulia Suarato Andrea Armirotti Rosalia Bertorelli Giorgio Mancini Doriana Debellis Athanassia Athanassiou
author_facet	Maria Elena Antinori Marco Contardi Giulia Suarato Andrea Armirotti Rosalia Bertorelli Giorgio Mancini Doriana Debellis Athanassia Athanassiou
author_sort	Maria Elena Antinori
title	Advanced mycelium materials as potential self-growing biomedical scaffolds
title_short	Advanced mycelium materials as potential self-growing biomedical scaffolds
title_full	Advanced mycelium materials as potential self-growing biomedical scaffolds
title_fullStr	Advanced mycelium materials as potential self-growing biomedical scaffolds
title_full_unstemmed	Advanced mycelium materials as potential self-growing biomedical scaffolds
title_sort	advanced mycelium materials as potential self-growing biomedical scaffolds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c024dc1765d4958997b3389a94e425e
work_keys_str_mv	AT mariaelenaantinori advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds AT marcocontardi advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds AT giuliasuarato advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds AT andreaarmirotti advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds AT rosaliabertorelli advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds AT giorgiomancini advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds AT dorianadebellis advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds AT athanassiaathanassiou advancedmyceliummaterialsaspotentialselfgrowingbiomedicalscaffolds
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Advanced mycelium materials as potential self-growing biomedical scaffolds

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