Optimal management of dactylitis in patients with psoriatic arthritis

Toshiyuki YamamotoDepartment of Dermatology, Fukushima Medical University, Fukushima, JapanAbstract: Psoriatic arthritis (PsA) is an inflammatory arthropathy associated with cutaneous psoriasis, which is currently classified as a seronegative spondyloarthropathy. The presence of cutaneous psoriasis...

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Autor principal:	Yamamoto T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/7c0314bdaa024156832ef1ad06eb7cd2
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spelling	oai:doaj.org-article:7c0314bdaa024156832ef1ad06eb7cd22021-12-02T05:11:12ZOptimal management of dactylitis in patients with psoriatic arthritis1179-156Xhttps://doaj.org/article/7c0314bdaa024156832ef1ad06eb7cd22015-09-01T00:00:00Zhttps://www.dovepress.com/optimal-management-of-dactylitis-in-patients-with-psoriatic-arthritis-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XToshiyuki YamamotoDepartment of Dermatology, Fukushima Medical University, Fukushima, JapanAbstract: Psoriatic arthritis (PsA) is an inflammatory arthropathy associated with cutaneous psoriasis, which is currently classified as a seronegative spondyloarthropathy. The presence of cutaneous psoriasis is important for correct and early diagnosis of PsA, because the onset of cutaneous lesions usually precedes the appearance of joint manifestation. Thus, dermatologists are able to detect the condition at its inception. PsA has several unique characteristics such as enthesopathy, dactylitis, and abnormal bone remodeling. In particular, dactylitis occurs on the easily observed sites such as digits, and is thus a significant indicator of PsA. It is important to observe not only the fingers but also the toes, because dactylitis involves both digits of the hands and feet. Recently, new ideas regarding the involvement of the interleukin (IL)-23/Th17 axis have emerged, and the dramatic effects of targeting therapies have highlighted the physiological roles of key cytokines such as tumor necrosis factor-α, IL-17A, and IL-23 in psoriasis. As recent insights are shedding light on the pathogenesis of PsA, understanding of the pathogenesis of dactylitis and enthesitis are also progressing. In this article, current views on the optimal management of dactylitis are discussed.Keywords: pathogenesis, therapy, enthesitis, tenosynovitisYamamoto TDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2015, Iss default, Pp 55-62 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Yamamoto T Optimal management of dactylitis in patients with psoriatic arthritis
description	Toshiyuki YamamotoDepartment of Dermatology, Fukushima Medical University, Fukushima, JapanAbstract: Psoriatic arthritis (PsA) is an inflammatory arthropathy associated with cutaneous psoriasis, which is currently classified as a seronegative spondyloarthropathy. The presence of cutaneous psoriasis is important for correct and early diagnosis of PsA, because the onset of cutaneous lesions usually precedes the appearance of joint manifestation. Thus, dermatologists are able to detect the condition at its inception. PsA has several unique characteristics such as enthesopathy, dactylitis, and abnormal bone remodeling. In particular, dactylitis occurs on the easily observed sites such as digits, and is thus a significant indicator of PsA. It is important to observe not only the fingers but also the toes, because dactylitis involves both digits of the hands and feet. Recently, new ideas regarding the involvement of the interleukin (IL)-23/Th17 axis have emerged, and the dramatic effects of targeting therapies have highlighted the physiological roles of key cytokines such as tumor necrosis factor-α, IL-17A, and IL-23 in psoriasis. As recent insights are shedding light on the pathogenesis of PsA, understanding of the pathogenesis of dactylitis and enthesitis are also progressing. In this article, current views on the optimal management of dactylitis are discussed.Keywords: pathogenesis, therapy, enthesitis, tenosynovitis
format	article
author	Yamamoto T
author_facet	Yamamoto T
author_sort	Yamamoto T
title	Optimal management of dactylitis in patients with psoriatic arthritis
title_short	Optimal management of dactylitis in patients with psoriatic arthritis
title_full	Optimal management of dactylitis in patients with psoriatic arthritis
title_fullStr	Optimal management of dactylitis in patients with psoriatic arthritis
title_full_unstemmed	Optimal management of dactylitis in patients with psoriatic arthritis
title_sort	optimal management of dactylitis in patients with psoriatic arthritis
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/7c0314bdaa024156832ef1ad06eb7cd2
work_keys_str_mv	AT yamamotot optimalmanagementofdactylitisinpatientswithpsoriaticarthritis
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Optimal management of dactylitis in patients with psoriatic arthritis

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