Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing

Abstract Substance abuse and addiction are worldwide concerns. In China, populated with over 1.3 billion people, emerging studies show a steady increase in substance abuse and substance-related problems. Some of the major challenges include a lack of an effective evaluation platform to determine the...

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Autores principales:	Yu Xu, Zhenrong Xie, Huawei Wang, Zongwen Shen, Youbing Guo, Yunhong Gao, Xin Chen, Qiang Wu, Xuejun Li, Kunhua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c068b7588af4d72b94cdbe0b1d1c26e
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spelling	oai:doaj.org-article:7c068b7588af4d72b94cdbe0b1d1c26e2021-12-02T15:06:08ZBacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing10.1038/s41598-017-03706-92045-2322https://doaj.org/article/7c068b7588af4d72b94cdbe0b1d1c26e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03706-9https://doaj.org/toc/2045-2322Abstract Substance abuse and addiction are worldwide concerns. In China, populated with over 1.3 billion people, emerging studies show a steady increase in substance abuse and substance-related problems. Some of the major challenges include a lack of an effective evaluation platform to determine the health status of substance-addicted subjects. It is known that the intestinal microbiota is associated to the occurrence and development of human diseases. However, the changes of bacterial diversity of intestinal microbiota in substance-addicted subjects have not been clearly characterized. Herein, we examined the composition and diversity of intestinal microbiota in 45 patients with substance use disorders (SUDs) and in 48 healthy controls (HCs). The results show that the observed species diversity index and the abundance of Thauera, Paracoccus, and Prevotella are significantly higher in SUDs compared to HCs. The functional diversity of the putative metagenomes analysis reveals that pathways including translation, DNA replication and repair, and cell growth and death are over-represented while cellular processes and signaling, and metabolism are under-represented in SUDs. Overall, the analyses show that there seem to be changes in the microbiota that are associated with substance use across an array of SUDs, providing fundamental knowledge for future research in substance-addiction assessment tests.Yu XuZhenrong XieHuawei WangZongwen ShenYoubing GuoYunhong GaoXin ChenQiang WuXuejun LiKunhua WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Xu Zhenrong Xie Huawei Wang Zongwen Shen Youbing Guo Yunhong Gao Xin Chen Qiang Wu Xuejun Li Kunhua Wang Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing
description	Abstract Substance abuse and addiction are worldwide concerns. In China, populated with over 1.3 billion people, emerging studies show a steady increase in substance abuse and substance-related problems. Some of the major challenges include a lack of an effective evaluation platform to determine the health status of substance-addicted subjects. It is known that the intestinal microbiota is associated to the occurrence and development of human diseases. However, the changes of bacterial diversity of intestinal microbiota in substance-addicted subjects have not been clearly characterized. Herein, we examined the composition and diversity of intestinal microbiota in 45 patients with substance use disorders (SUDs) and in 48 healthy controls (HCs). The results show that the observed species diversity index and the abundance of Thauera, Paracoccus, and Prevotella are significantly higher in SUDs compared to HCs. The functional diversity of the putative metagenomes analysis reveals that pathways including translation, DNA replication and repair, and cell growth and death are over-represented while cellular processes and signaling, and metabolism are under-represented in SUDs. Overall, the analyses show that there seem to be changes in the microbiota that are associated with substance use across an array of SUDs, providing fundamental knowledge for future research in substance-addiction assessment tests.
format	article
author	Yu Xu Zhenrong Xie Huawei Wang Zongwen Shen Youbing Guo Yunhong Gao Xin Chen Qiang Wu Xuejun Li Kunhua Wang
author_facet	Yu Xu Zhenrong Xie Huawei Wang Zongwen Shen Youbing Guo Yunhong Gao Xin Chen Qiang Wu Xuejun Li Kunhua Wang
author_sort	Yu Xu
title	Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing
title_short	Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing
title_full	Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing
title_fullStr	Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing
title_full_unstemmed	Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing
title_sort	bacterial diversity of intestinal microbiota in patients with substance use disorders revealed by 16s rrna gene deep sequencing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7c068b7588af4d72b94cdbe0b1d1c26e
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Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing

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