Plasmodium translocon component EXP2 facilitates hepatocyte invasion

While the role of Plasmodium EXP2 protein as translocon component of blood stage parasites is established, its functional role in liver stage parasites remains unclear. Here, Mello-Vieira et al. reveal that EXP2 pore-forming activity induces hepatocyte membrane repair and hence is critical for hepat...

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Autores principales:	João Mello-Vieira, Francisco J. Enguita, Tania F. de Koning-Ward, Vanessa Zuzarte-Luís, Maria M. Mota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c06f4db9999411dad1ae293d10c1e41
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spelling	oai:doaj.org-article:7c06f4db9999411dad1ae293d10c1e412021-12-02T16:56:33ZPlasmodium translocon component EXP2 facilitates hepatocyte invasion10.1038/s41467-020-19492-42041-1723https://doaj.org/article/7c06f4db9999411dad1ae293d10c1e412020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19492-4https://doaj.org/toc/2041-1723While the role of Plasmodium EXP2 protein as translocon component of blood stage parasites is established, its functional role in liver stage parasites remains unclear. Here, Mello-Vieira et al. reveal that EXP2 pore-forming activity induces hepatocyte membrane repair and hence is critical for hepatocyte invasion.João Mello-VieiraFrancisco J. EnguitaTania F. de Koning-WardVanessa Zuzarte-LuísMaria M. MotaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q João Mello-Vieira Francisco J. Enguita Tania F. de Koning-Ward Vanessa Zuzarte-Luís Maria M. Mota Plasmodium translocon component EXP2 facilitates hepatocyte invasion
description	While the role of Plasmodium EXP2 protein as translocon component of blood stage parasites is established, its functional role in liver stage parasites remains unclear. Here, Mello-Vieira et al. reveal that EXP2 pore-forming activity induces hepatocyte membrane repair and hence is critical for hepatocyte invasion.
format	article
author	João Mello-Vieira Francisco J. Enguita Tania F. de Koning-Ward Vanessa Zuzarte-Luís Maria M. Mota
author_facet	João Mello-Vieira Francisco J. Enguita Tania F. de Koning-Ward Vanessa Zuzarte-Luís Maria M. Mota
author_sort	João Mello-Vieira
title	Plasmodium translocon component EXP2 facilitates hepatocyte invasion
title_short	Plasmodium translocon component EXP2 facilitates hepatocyte invasion
title_full	Plasmodium translocon component EXP2 facilitates hepatocyte invasion
title_fullStr	Plasmodium translocon component EXP2 facilitates hepatocyte invasion
title_full_unstemmed	Plasmodium translocon component EXP2 facilitates hepatocyte invasion
title_sort	plasmodium translocon component exp2 facilitates hepatocyte invasion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7c06f4db9999411dad1ae293d10c1e41
work_keys_str_mv	AT joaomellovieira plasmodiumtransloconcomponentexp2facilitateshepatocyteinvasion AT franciscojenguita plasmodiumtransloconcomponentexp2facilitateshepatocyteinvasion AT taniafdekoningward plasmodiumtransloconcomponentexp2facilitateshepatocyteinvasion AT vanessazuzarteluis plasmodiumtransloconcomponentexp2facilitateshepatocyteinvasion AT mariammota plasmodiumtransloconcomponentexp2facilitateshepatocyteinvasion
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Plasmodium translocon component EXP2 facilitates hepatocyte invasion

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