SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity
NK cells control SIV infection in secondary lymphoid tissues in the natural host that typically doesn’t progress toward disease. Here the authors show that this control is associated with terminal NK cell differentiation and improved MHC-E-dependent activity lacking in pathogenic SIV infection.
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Nature Portfolio
2021
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oai:doaj.org-article:7c09c41f3ce44f41931d8a99a69c119f2021-12-02T15:52:50ZSIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity10.1038/s41467-021-21402-12041-1723https://doaj.org/article/7c09c41f3ce44f41931d8a99a69c119f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21402-1https://doaj.org/toc/2041-1723NK cells control SIV infection in secondary lymphoid tissues in the natural host that typically doesn’t progress toward disease. Here the authors show that this control is associated with terminal NK cell differentiation and improved MHC-E-dependent activity lacking in pathogenic SIV infection.Nicolas HuotPhilippe RascleCaroline PetitdemangeVanessa ContrerasChristina M. StürzelEduard BaqueroJustin L. HarperCaroline PassaesRachel LegendreHugo VaretYoann MadecUlrike SauermannChristiane Stahl-HennigJacob NattermannAsier Saez-CirionRoger Le GrandR. Keith ReevesMirko PaiardiniFrank KirchhoffBeatrice JacquelinMichaela Müller-TrutwinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nicolas Huot Philippe Rascle Caroline Petitdemange Vanessa Contreras Christina M. Stürzel Eduard Baquero Justin L. Harper Caroline Passaes Rachel Legendre Hugo Varet Yoann Madec Ulrike Sauermann Christiane Stahl-Hennig Jacob Nattermann Asier Saez-Cirion Roger Le Grand R. Keith Reeves Mirko Paiardini Frank Kirchhoff Beatrice Jacquelin Michaela Müller-Trutwin SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity |
| description |
NK cells control SIV infection in secondary lymphoid tissues in the natural host that typically doesn’t progress toward disease. Here the authors show that this control is associated with terminal NK cell differentiation and improved MHC-E-dependent activity lacking in pathogenic SIV infection. |
| format |
article |
| author |
Nicolas Huot Philippe Rascle Caroline Petitdemange Vanessa Contreras Christina M. Stürzel Eduard Baquero Justin L. Harper Caroline Passaes Rachel Legendre Hugo Varet Yoann Madec Ulrike Sauermann Christiane Stahl-Hennig Jacob Nattermann Asier Saez-Cirion Roger Le Grand R. Keith Reeves Mirko Paiardini Frank Kirchhoff Beatrice Jacquelin Michaela Müller-Trutwin |
| author_facet |
Nicolas Huot Philippe Rascle Caroline Petitdemange Vanessa Contreras Christina M. Stürzel Eduard Baquero Justin L. Harper Caroline Passaes Rachel Legendre Hugo Varet Yoann Madec Ulrike Sauermann Christiane Stahl-Hennig Jacob Nattermann Asier Saez-Cirion Roger Le Grand R. Keith Reeves Mirko Paiardini Frank Kirchhoff Beatrice Jacquelin Michaela Müller-Trutwin |
| author_sort |
Nicolas Huot |
| title |
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity |
| title_short |
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity |
| title_full |
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity |
| title_fullStr |
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity |
| title_full_unstemmed |
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity |
| title_sort |
siv-induced terminally differentiated adaptive nk cells in lymph nodes associated with enhanced mhc-e restricted activity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7c09c41f3ce44f41931d8a99a69c119f |
| work_keys_str_mv |
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1718385580182601728 |