Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway

Here, through applying 2,6-bis(4′-carboxyl-phenyl)pyridine (H2L), a rigid ligand featuring both carboxylic acid and pyridine groups, a new coordination polymer containing Na(I) has been generated with the reaction between H2L ligand and NaNO3 in a water and DMF mixed solvent, and its chemical compos...

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Autores principales:	Jun Zhang, Zhi-Nan Liu, Guo-Hua Deng
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7c108bf4daee4aeaa755dbf4e175deda
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spelling	oai:doaj.org-article:7c108bf4daee4aeaa755dbf4e175deda2021-11-29T00:56:05ZAnticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway1687-846910.1155/2021/9403333https://doaj.org/article/7c108bf4daee4aeaa755dbf4e175deda2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9403333https://doaj.org/toc/1687-8469Here, through applying 2,6-bis(4′-carboxyl-phenyl)pyridine (H2L), a rigid ligand featuring both carboxylic acid and pyridine groups, a new coordination polymer containing Na(I) has been generated with the reaction between H2L ligand and NaNO3 in a water and DMF mixed solvent, and its chemical composition is [Na2L]n. Furthermore, the antiproliferative activity of Na(I) complex against the HXO-Rb44 retinoblastoma cells was detected with CCK-8 assay. Hoechst staining along with Annexin V-FITC/PI revealed that Na(I) complex induces the HXO-Rb44 retinoblastoma cells apoptosis. Flow cytometry analysis of reactive oxygen species (ROS) showed that Na(I) complex significantly increases the level of intracellular ROS. Importantly, western blot analysis revealed that Na(I) complex might induce apoptosis through inactivation of PI3K/AKT/mTOR pathway.Jun ZhangZhi-Nan LiuGuo-Hua DengHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jun Zhang Zhi-Nan Liu Guo-Hua Deng Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway
description	Here, through applying 2,6-bis(4′-carboxyl-phenyl)pyridine (H2L), a rigid ligand featuring both carboxylic acid and pyridine groups, a new coordination polymer containing Na(I) has been generated with the reaction between H2L ligand and NaNO3 in a water and DMF mixed solvent, and its chemical composition is [Na2L]n. Furthermore, the antiproliferative activity of Na(I) complex against the HXO-Rb44 retinoblastoma cells was detected with CCK-8 assay. Hoechst staining along with Annexin V-FITC/PI revealed that Na(I) complex induces the HXO-Rb44 retinoblastoma cells apoptosis. Flow cytometry analysis of reactive oxygen species (ROS) showed that Na(I) complex significantly increases the level of intracellular ROS. Importantly, western blot analysis revealed that Na(I) complex might induce apoptosis through inactivation of PI3K/AKT/mTOR pathway.
format	article
author	Jun Zhang Zhi-Nan Liu Guo-Hua Deng
author_facet	Jun Zhang Zhi-Nan Liu Guo-Hua Deng
author_sort	Jun Zhang
title	Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway
title_short	Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway
title_full	Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway
title_fullStr	Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway
title_full_unstemmed	Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway
title_sort	anticancer activity of new na(i) complex on retinoblastoma cells via inhibiting pi3k/akt/mtor pathway
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/7c108bf4daee4aeaa755dbf4e175deda
work_keys_str_mv	AT junzhang anticanceractivityofnewnaicomplexonretinoblastomacellsviainhibitingpi3kaktmtorpathway AT zhinanliu anticanceractivityofnewnaicomplexonretinoblastomacellsviainhibitingpi3kaktmtorpathway AT guohuadeng anticanceractivityofnewnaicomplexonretinoblastomacellsviainhibitingpi3kaktmtorpathway
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Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway

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