The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome

Abstract Aggregation-induced quenching of porphyrin molecules as photosensitizer significantly reduces the quantum yield of the singlet oxygen generation, and it is able to decrease the efficacy of photodynamic therapy. We utilized amphiphilic copolymers in this work to precisely control porphyrin H...

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Autores principales:	Seyed Milad Safar Sajadi, Sepideh Khoee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c117367ca3840fbaa0902795e0f7461
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spelling	oai:doaj.org-article:7c117367ca3840fbaa0902795e0f74612021-12-02T10:44:21ZThe simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome10.1038/s41598-021-82256-72045-2322https://doaj.org/article/7c117367ca3840fbaa0902795e0f74612021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82256-7https://doaj.org/toc/2045-2322Abstract Aggregation-induced quenching of porphyrin molecules as photosensitizer significantly reduces the quantum yield of the singlet oxygen generation, and it is able to decrease the efficacy of photodynamic therapy. We utilized amphiphilic copolymers in this work to precisely control porphyrin H-type and J-type aggregations in water. The amphiphilic copolymer bearing azobenzene, β-cyclodextrin, and porphyrin was successfully synthesized by the atom transfer radical polymerization technique. The azobenzene and β-cyclodextrin complex, as a host–guest supramolecular interaction, has great potential in the design of light-responsive nanocarriers. The amphiphilic block copolymer can be self-assembled into polymersomes, whose application in the generation of singlet oxygen has been also tested. We further demonstrate that, due to the stable H- and J-aggregates of porphyrin, which act as noncovalent cross-linking points, the structure of polymersomes can be reversible under light-stimulus. This formation method has the advantage of allowing for both the encapsulation of hydrophilic and hydrophobic molecules and release upon external light without any distinguishable changes in the structure. Furthermore, the morphology and particle size distribution of the polymersomes were also investigated by using transition electron microscopy, dynamic light scattering, and field emission scanning electron microscopy.Seyed Milad Safar SajadiSepideh KhoeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seyed Milad Safar Sajadi Sepideh Khoee The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome
description	Abstract Aggregation-induced quenching of porphyrin molecules as photosensitizer significantly reduces the quantum yield of the singlet oxygen generation, and it is able to decrease the efficacy of photodynamic therapy. We utilized amphiphilic copolymers in this work to precisely control porphyrin H-type and J-type aggregations in water. The amphiphilic copolymer bearing azobenzene, β-cyclodextrin, and porphyrin was successfully synthesized by the atom transfer radical polymerization technique. The azobenzene and β-cyclodextrin complex, as a host–guest supramolecular interaction, has great potential in the design of light-responsive nanocarriers. The amphiphilic block copolymer can be self-assembled into polymersomes, whose application in the generation of singlet oxygen has been also tested. We further demonstrate that, due to the stable H- and J-aggregates of porphyrin, which act as noncovalent cross-linking points, the structure of polymersomes can be reversible under light-stimulus. This formation method has the advantage of allowing for both the encapsulation of hydrophilic and hydrophobic molecules and release upon external light without any distinguishable changes in the structure. Furthermore, the morphology and particle size distribution of the polymersomes were also investigated by using transition electron microscopy, dynamic light scattering, and field emission scanning electron microscopy.
format	article
author	Seyed Milad Safar Sajadi Sepideh Khoee
author_facet	Seyed Milad Safar Sajadi Sepideh Khoee
author_sort	Seyed Milad Safar Sajadi
title	The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome
title_short	The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome
title_full	The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome
title_fullStr	The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome
title_full_unstemmed	The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome
title_sort	simultaneous role of porphyrins’ h- and j- aggregates and host–guest chemistry on the fabrication of reversible dextran-pmma polymersome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c117367ca3840fbaa0902795e0f7461
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The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome

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