Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms

Abstract We herein described a rapid, sensitive, and selective colorimetric sensing platform for biothiols in human serum, which relies on the dual functions of biothiols as anti-etching and aggregating agent for silver nanoprisms (AgNPRs). In principle, the target biothiols that bind to the surface...

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Autores principales:	Pei Li, Sang Mo Lee, Hyo Yong Kim, Soohyun Kim, Steve Park, Ki Soo Park, Hyun Gyu Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c1230c091e5477e8d30ce20f934874d
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spelling	oai:doaj.org-article:7c1230c091e5477e8d30ce20f934874d2021-12-02T12:11:40ZColorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms10.1038/s41598-021-83433-42045-2322https://doaj.org/article/7c1230c091e5477e8d30ce20f934874d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83433-4https://doaj.org/toc/2045-2322Abstract We herein described a rapid, sensitive, and selective colorimetric sensing platform for biothiols in human serum, which relies on the dual functions of biothiols as anti-etching and aggregating agent for silver nanoprisms (AgNPRs). In principle, the target biothiols that bind to the surface of AgNPRs through Ag–S covalent interactions protect the AgNPRs from being etched by chloride ion (Cl−) in human serum, thus exhibiting the blue/purple color that is indicative of AgNPRs. On the other hand, the color of AgNPRs turned to yellow in the absence of biothiols or the presence of non-sulfur-containing amino acids, indicating the formation of small silver nanoparticles (AgNPs). Importantly, we found that individual biothiols (Hcy, Cys, and GSH) exert not only the anti-etching effect, but also the aggregating effect on AgNPRs, which can be modulated by simply tuning the pH conditions, and this consequently allows for the discriminative detection of each biothiol. Based on this simple and cost-effective strategy, we successfully determined the Hcy, Cys, and GSH in human serum with high sensitivity and selectivity within 10 min, demonstrating the diagnostic capability and potential in practical applications.Pei LiSang Mo LeeHyo Yong KimSoohyun KimSteve ParkKi Soo ParkHyun Gyu ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pei Li Sang Mo Lee Hyo Yong Kim Soohyun Kim Steve Park Ki Soo Park Hyun Gyu Park Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms
description	Abstract We herein described a rapid, sensitive, and selective colorimetric sensing platform for biothiols in human serum, which relies on the dual functions of biothiols as anti-etching and aggregating agent for silver nanoprisms (AgNPRs). In principle, the target biothiols that bind to the surface of AgNPRs through Ag–S covalent interactions protect the AgNPRs from being etched by chloride ion (Cl−) in human serum, thus exhibiting the blue/purple color that is indicative of AgNPRs. On the other hand, the color of AgNPRs turned to yellow in the absence of biothiols or the presence of non-sulfur-containing amino acids, indicating the formation of small silver nanoparticles (AgNPs). Importantly, we found that individual biothiols (Hcy, Cys, and GSH) exert not only the anti-etching effect, but also the aggregating effect on AgNPRs, which can be modulated by simply tuning the pH conditions, and this consequently allows for the discriminative detection of each biothiol. Based on this simple and cost-effective strategy, we successfully determined the Hcy, Cys, and GSH in human serum with high sensitivity and selectivity within 10 min, demonstrating the diagnostic capability and potential in practical applications.
format	article
author	Pei Li Sang Mo Lee Hyo Yong Kim Soohyun Kim Steve Park Ki Soo Park Hyun Gyu Park
author_facet	Pei Li Sang Mo Lee Hyo Yong Kim Soohyun Kim Steve Park Ki Soo Park Hyun Gyu Park
author_sort	Pei Li
title	Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms
title_short	Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms
title_full	Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms
title_fullStr	Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms
title_full_unstemmed	Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms
title_sort	colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c1230c091e5477e8d30ce20f934874d
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Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms

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