Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.

This study was designed to evaluate the possible antioxidant and antihepatocarcinogeniceffects of soybean (SB) and Nigella sativa (NS) in rats administered nitrosamineprecursors dibutylamine and sodium nitrate in the drinking water.Rats were randomly divided into four groups, each containing 48 anim...

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Autores principales:	A.A. El-Aaser, M.H. Kalifa, K. EL-Magraby, H.A. Ibrahim, M. Hessien, I. Abdel Salam, M. Morad, 1S. El Gendy
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2007
Materias:	Soybean Nigella sativa Antioxidant Nitrosamine Oxidative Stress Hepatocarcinogenesis Her-2/neu p53 bcl-2 GSH NO. Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/7c13521c1fc64917b64da36e2d08e7cb
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id	oai:doaj.org-article:7c13521c1fc64917b64da36e2d08e7cb
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spelling	oai:doaj.org-article:7c13521c1fc64917b64da36e2d08e7cb2021-12-02T12:40:08ZEvaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.0250-46851303-829Xhttps://doaj.org/article/7c13521c1fc64917b64da36e2d08e7cb2007-05-01T00:00:00Zhttp://www.turkjbiochem.com/2007/005.pdfhttps://doaj.org/toc/0250-4685https://doaj.org/toc/1303-829XThis study was designed to evaluate the possible antioxidant and antihepatocarcinogeniceffects of soybean (SB) and Nigella sativa (NS) in rats administered nitrosamineprecursors dibutylamine and sodium nitrate in the drinking water.Rats were randomly divided into four groups, each containing 48 animals. GroupI (control), group II (dibutylamine (DBA) + NaNO3), group III (DBA/NaNO3 + SBtreated) and group IV (DBA/NaNO3 + NS treated). Markers of oxidative stress [reducedglutathione (GSH) and nitric oxide (NO)] and the levels of HER-2/neu, bcl-2and p53 proteins were investigated in rats liver after 2, 4, 6, 8, 10 and 12 months.The data revealed an improvement in the status of oxidative stress represented asthe compensation of GSH levels after 2 and 4 months and reduction of NO levelsafter 2 months; a significant improvement in the levels of HER-2/neu protein after6 and 4 months in rats fed SB and NS, respectively. Although, the level of p53protein was ameliorated compared with the treated with nitrosamine precursor rats,it was maintained in a lower levels compared with the time matched points of thenormal controls until 12 months Both SB and NS improved the levels of bcl-2 after2 months in both groups. The data suggested that oral feeding of the diet containingSB and NS antagonized the oxidative stress effects induced by DBA/NaNO3.A.A. El-AaserM.H. KalifaK. EL-MagrabyH.A. Ibrahim,M. Hessien,I. Abdel Salam,M. Morad1S. El Gendy,De GruyterarticleSoybeanNigella sativaAntioxidantNitrosamineOxidative StressHepatocarcinogenesisHer-2/neup53bcl-2GSHNO.BiochemistryQD415-436ENTürk Biyokimya Dergisi, Vol 32, Iss 1, Pp 5-11 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Soybean Nigella sativa Antioxidant Nitrosamine Oxidative Stress Hepatocarcinogenesis Her-2/neu p53 bcl-2 GSH NO. Biochemistry QD415-436
spellingShingle	Soybean Nigella sativa Antioxidant Nitrosamine Oxidative Stress Hepatocarcinogenesis Her-2/neu p53 bcl-2 GSH NO. Biochemistry QD415-436 A.A. El-Aaser M.H. Kalifa K. EL-Magraby H.A. Ibrahim, M. Hessien, I. Abdel Salam, M. Morad 1S. El Gendy, Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.
description	This study was designed to evaluate the possible antioxidant and antihepatocarcinogeniceffects of soybean (SB) and Nigella sativa (NS) in rats administered nitrosamineprecursors dibutylamine and sodium nitrate in the drinking water.Rats were randomly divided into four groups, each containing 48 animals. GroupI (control), group II (dibutylamine (DBA) + NaNO3), group III (DBA/NaNO3 + SBtreated) and group IV (DBA/NaNO3 + NS treated). Markers of oxidative stress [reducedglutathione (GSH) and nitric oxide (NO)] and the levels of HER-2/neu, bcl-2and p53 proteins were investigated in rats liver after 2, 4, 6, 8, 10 and 12 months.The data revealed an improvement in the status of oxidative stress represented asthe compensation of GSH levels after 2 and 4 months and reduction of NO levelsafter 2 months; a significant improvement in the levels of HER-2/neu protein after6 and 4 months in rats fed SB and NS, respectively. Although, the level of p53protein was ameliorated compared with the treated with nitrosamine precursor rats,it was maintained in a lower levels compared with the time matched points of thenormal controls until 12 months Both SB and NS improved the levels of bcl-2 after2 months in both groups. The data suggested that oral feeding of the diet containingSB and NS antagonized the oxidative stress effects induced by DBA/NaNO3.
format	article
author	A.A. El-Aaser M.H. Kalifa K. EL-Magraby H.A. Ibrahim, M. Hessien, I. Abdel Salam, M. Morad 1S. El Gendy,
author_facet	A.A. El-Aaser M.H. Kalifa K. EL-Magraby H.A. Ibrahim, M. Hessien, I. Abdel Salam, M. Morad 1S. El Gendy,
author_sort	A.A. El-Aaser
title	Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.
title_short	Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.
title_full	Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.
title_fullStr	Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.
title_full_unstemmed	Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.
title_sort	evaluation of the possible antioxidant effects of soybean and nigella sativa during experimental hepatocarcinogenesis by nitrosamine precursors.
publisher	De Gruyter
publishDate	2007
url	https://doaj.org/article/7c13521c1fc64917b64da36e2d08e7cb
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Evaluation of the Possible Antioxidant Effects of Soybean and Nigella Sativa During Experimental Hepatocarcinogenesis by Nitrosamine Precursors.

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