Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells

During myocardial infarction, microRNAs (myo-miRs) are released into the circulation. Here Cheng et al. show that myo-miRs carried in exosomes are transferred to the bone marrow (BM), downregulate expression of CXCR4 in mononuclear cells, and increase the number of circulating BM progenitor cells, t...

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Autores principales:	Min Cheng, Junjie Yang, Xiaoqi Zhao, Eric Zhang, Qiutang Zeng, Yang Yu, Liu Yang, Bangwei Wu, Guiwen Yi, Xiaobo Mao, Kai Huang, Nianguo Dong, Min Xie, Nita A. Limdi, Sumanth D. Prabhu, Jianyi Zhang, Gangjian Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c19cf08d8cd4a27ab92b4b065c22fcd
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spelling	oai:doaj.org-article:7c19cf08d8cd4a27ab92b4b065c22fcd2021-12-02T16:58:25ZCirculating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells10.1038/s41467-019-08895-72041-1723https://doaj.org/article/7c19cf08d8cd4a27ab92b4b065c22fcd2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08895-7https://doaj.org/toc/2041-1723During myocardial infarction, microRNAs (myo-miRs) are released into the circulation. Here Cheng et al. show that myo-miRs carried in exosomes are transferred to the bone marrow (BM), downregulate expression of CXCR4 in mononuclear cells, and increase the number of circulating BM progenitor cells, thus orchestrating a systemic response to myocardial injury.Min ChengJunjie YangXiaoqi ZhaoEric ZhangQiutang ZengYang YuLiu YangBangwei WuGuiwen YiXiaobo MaoKai HuangNianguo DongMin XieNita A. LimdiSumanth D. PrabhuJianyi ZhangGangjian QinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min Cheng Junjie Yang Xiaoqi Zhao Eric Zhang Qiutang Zeng Yang Yu Liu Yang Bangwei Wu Guiwen Yi Xiaobo Mao Kai Huang Nianguo Dong Min Xie Nita A. Limdi Sumanth D. Prabhu Jianyi Zhang Gangjian Qin Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
description	During myocardial infarction, microRNAs (myo-miRs) are released into the circulation. Here Cheng et al. show that myo-miRs carried in exosomes are transferred to the bone marrow (BM), downregulate expression of CXCR4 in mononuclear cells, and increase the number of circulating BM progenitor cells, thus orchestrating a systemic response to myocardial injury.
format	article
author	Min Cheng Junjie Yang Xiaoqi Zhao Eric Zhang Qiutang Zeng Yang Yu Liu Yang Bangwei Wu Guiwen Yi Xiaobo Mao Kai Huang Nianguo Dong Min Xie Nita A. Limdi Sumanth D. Prabhu Jianyi Zhang Gangjian Qin
author_facet	Min Cheng Junjie Yang Xiaoqi Zhao Eric Zhang Qiutang Zeng Yang Yu Liu Yang Bangwei Wu Guiwen Yi Xiaobo Mao Kai Huang Nianguo Dong Min Xie Nita A. Limdi Sumanth D. Prabhu Jianyi Zhang Gangjian Qin
author_sort	Min Cheng
title	Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
title_short	Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
title_full	Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
title_fullStr	Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
title_full_unstemmed	Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
title_sort	circulating myocardial micrornas from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7c19cf08d8cd4a27ab92b4b065c22fcd
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Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells

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