Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy

Background: The serotonin, copper, and ceruloplasmin markers are altered in various cancers, including breast cancer. It has been reported that these markers have the potential to be used in the study of cancer recurrence. The purpose of this study was to compare the levels of serotonin, copper and...

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Autores principales:	Sahar Rezaei, Hemen Moradi-sardareh, Mohammad-Hasan Khadem Ansari, Fatemeh Kheradmand
Formato:	article
Lenguaje:	EN
Publicado:	Kaviani Breast Disease Institute 2021
Materias:	Serotonin Ceruloplasmin Copper CEA CA15-3 Breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7c1a8d5b93fe4f29a9a305763ab44913
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spelling	oai:doaj.org-article:7c1a8d5b93fe4f29a9a305763ab449132021-12-04T02:18:56ZComparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy10.32768/abc.202184312-3172383-0433https://doaj.org/article/7c1a8d5b93fe4f29a9a305763ab449132021-10-01T00:00:00Zhttps://www.archbreastcancer.com/index.php/abc/article/view/412https://doaj.org/toc/2383-0433 Background: The serotonin, copper, and ceruloplasmin markers are altered in various cancers, including breast cancer. It has been reported that these markers have the potential to be used in the study of cancer recurrence. The purpose of this study was to compare the levels of serotonin, copper and ceruloplasmin besides the routine breast cancer markers such as CEA and CA15-3 in the blood sample of patients with invasive ductal breast cancer, before and after chemotherapy. Methods: This study was performed on 30 patients with breast cancer. Blood samples were taken from the patients before and after chemotherapy. Necessary data including age, tumor grade and status of Her-2, ER, PR receptors were obtained from patient records. Serotonin, CEA and CA15-3 levels were measured by ELISA method. Ceruloplasmin and copper were measured by nephelometry and colorimetric methods, respectively. Results: Results showed a decrease in serotonin, ceruloplasmin, copper, CEA and CA15-3 after treatment but only the levels of serotonin and ceruloplasmin showed a steady decrease. No significant relationship was observed between tumor grade and ER-PR, Her-2 receptors. Conclusion: This study showed that chemotherapy resulted in steady decline in serotonin and ceruloplasmin levels but this decrease was not steady in levels of CA15-3 and CEA. Therefore, if our results are confirmed by further research, they can be considered as a viable alternative to routine markers in cancer recurrence after chemotherapy. Sahar RezaeiHemen Moradi-sardarehMohammad-Hasan Khadem AnsariFatemeh KheradmandKaviani Breast Disease InstitutearticleSerotonin CeruloplasminCopperCEACA15-3Breast cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENArchives of Breast Cancer (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Serotonin Ceruloplasmin Copper CEA CA15-3 Breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Serotonin Ceruloplasmin Copper CEA CA15-3 Breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sahar Rezaei Hemen Moradi-sardareh Mohammad-Hasan Khadem Ansari Fatemeh Kheradmand Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy
description	Background: The serotonin, copper, and ceruloplasmin markers are altered in various cancers, including breast cancer. It has been reported that these markers have the potential to be used in the study of cancer recurrence. The purpose of this study was to compare the levels of serotonin, copper and ceruloplasmin besides the routine breast cancer markers such as CEA and CA15-3 in the blood sample of patients with invasive ductal breast cancer, before and after chemotherapy. Methods: This study was performed on 30 patients with breast cancer. Blood samples were taken from the patients before and after chemotherapy. Necessary data including age, tumor grade and status of Her-2, ER, PR receptors were obtained from patient records. Serotonin, CEA and CA15-3 levels were measured by ELISA method. Ceruloplasmin and copper were measured by nephelometry and colorimetric methods, respectively. Results: Results showed a decrease in serotonin, ceruloplasmin, copper, CEA and CA15-3 after treatment but only the levels of serotonin and ceruloplasmin showed a steady decrease. No significant relationship was observed between tumor grade and ER-PR, Her-2 receptors. Conclusion: This study showed that chemotherapy resulted in steady decline in serotonin and ceruloplasmin levels but this decrease was not steady in levels of CA15-3 and CEA. Therefore, if our results are confirmed by further research, they can be considered as a viable alternative to routine markers in cancer recurrence after chemotherapy.
format	article
author	Sahar Rezaei Hemen Moradi-sardareh Mohammad-Hasan Khadem Ansari Fatemeh Kheradmand
author_facet	Sahar Rezaei Hemen Moradi-sardareh Mohammad-Hasan Khadem Ansari Fatemeh Kheradmand
author_sort	Sahar Rezaei
title	Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy
title_short	Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy
title_full	Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy
title_fullStr	Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy
title_full_unstemmed	Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy
title_sort	comparison of cea and ca15-3 markers with serotonin, ceruloplasmin and copper in breast cancer recurrence after chemotherapy
publisher	Kaviani Breast Disease Institute
publishDate	2021
url	https://doaj.org/article/7c1a8d5b93fe4f29a9a305763ab44913
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Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy

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