Programmable biomolecular switches for rewiring flux in Escherichia coli

Current flux rewiring technologies in metabolic engineering are mainly transcriptional regulation. Here, the authors build two sets of controllable protein units using engineered viral proteases and proteolytic signals, and utilize for increasing titers of shikimate and D-xylonate in E. coli.

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Autores principales:	Cong Gao, Jianshen Hou, Peng Xu, Liang Guo, Xiulai Chen, Guipeng Hu, Chao Ye, Harley Edwards, Jian Chen, Wei Chen, Liming Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c1b65f73bf441b69cc493442bde1117
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spelling	oai:doaj.org-article:7c1b65f73bf441b69cc493442bde11172021-12-02T16:58:26ZProgrammable biomolecular switches for rewiring flux in Escherichia coli10.1038/s41467-019-11793-72041-1723https://doaj.org/article/7c1b65f73bf441b69cc493442bde11172019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11793-7https://doaj.org/toc/2041-1723Current flux rewiring technologies in metabolic engineering are mainly transcriptional regulation. Here, the authors build two sets of controllable protein units using engineered viral proteases and proteolytic signals, and utilize for increasing titers of shikimate and D-xylonate in E. coli.Cong GaoJianshen HouPeng XuLiang GuoXiulai ChenGuipeng HuChao YeHarley EdwardsJian ChenWei ChenLiming LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cong Gao Jianshen Hou Peng Xu Liang Guo Xiulai Chen Guipeng Hu Chao Ye Harley Edwards Jian Chen Wei Chen Liming Liu Programmable biomolecular switches for rewiring flux in Escherichia coli
description	Current flux rewiring technologies in metabolic engineering are mainly transcriptional regulation. Here, the authors build two sets of controllable protein units using engineered viral proteases and proteolytic signals, and utilize for increasing titers of shikimate and D-xylonate in E. coli.
format	article
author	Cong Gao Jianshen Hou Peng Xu Liang Guo Xiulai Chen Guipeng Hu Chao Ye Harley Edwards Jian Chen Wei Chen Liming Liu
author_facet	Cong Gao Jianshen Hou Peng Xu Liang Guo Xiulai Chen Guipeng Hu Chao Ye Harley Edwards Jian Chen Wei Chen Liming Liu
author_sort	Cong Gao
title	Programmable biomolecular switches for rewiring flux in Escherichia coli
title_short	Programmable biomolecular switches for rewiring flux in Escherichia coli
title_full	Programmable biomolecular switches for rewiring flux in Escherichia coli
title_fullStr	Programmable biomolecular switches for rewiring flux in Escherichia coli
title_full_unstemmed	Programmable biomolecular switches for rewiring flux in Escherichia coli
title_sort	programmable biomolecular switches for rewiring flux in escherichia coli
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7c1b65f73bf441b69cc493442bde1117
work_keys_str_mv	AT conggao programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT jianshenhou programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT pengxu programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT liangguo programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT xiulaichen programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT guipenghu programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT chaoye programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT harleyedwards programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT jianchen programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT weichen programmablebiomolecularswitchesforrewiringfluxinescherichiacoli AT limingliu programmablebiomolecularswitchesforrewiringfluxinescherichiacoli
_version_	1718382338207907840

Programmable biomolecular switches for rewiring flux in Escherichia coli

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