Programmable biomolecular switches for rewiring flux in Escherichia coli
Current flux rewiring technologies in metabolic engineering are mainly transcriptional regulation. Here, the authors build two sets of controllable protein units using engineered viral proteases and proteolytic signals, and utilize for increasing titers of shikimate and D-xylonate in E. coli.
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Auteurs principaux: | Cong Gao, Jianshen Hou, Peng Xu, Liang Guo, Xiulai Chen, Guipeng Hu, Chao Ye, Harley Edwards, Jian Chen, Wei Chen, Liming Liu |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
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Sujets: | |
Accès en ligne: | https://doaj.org/article/7c1b65f73bf441b69cc493442bde1117 |
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