Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis

The purpose of the present study was to evaluate serum canine Cystatin-C (Cys-C) concentration for the prediction of renal function (RF) in dogs naturally infected with Babesia canis vogeli and Ehrlichia canis. A total of 46 dogs were enrolled into three groups. Group B included 16 dogs naturally in...

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Autores principales:	Didem PEKMEZCI, Kerem URAL, Nuran AYSUL, Murat GUZEL, Gulay CIFTCI
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2015
Materias:	renal function cystatin-c canine babesia canis vogeli ehrlichia canis Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/7c1d05d68fa3450098eac3058be1b701
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spelling	oai:doaj.org-article:7c1d05d68fa3450098eac3058be1b7012021-11-17T21:27:50ZAssessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis1820-744810.1515/acve-2015-0004https://doaj.org/article/7c1d05d68fa3450098eac3058be1b7012015-03-01T00:00:00Zhttps://doi.org/10.1515/acve-2015-0004https://doaj.org/toc/1820-7448The purpose of the present study was to evaluate serum canine Cystatin-C (Cys-C) concentration for the prediction of renal function (RF) in dogs naturally infected with Babesia canis vogeli and Ehrlichia canis. A total of 46 dogs were enrolled into three groups. Group B included 16 dogs naturally infected with B. c. vogeli, group E 10 dogs naturally infected with E. canis [dogs diagnosed as canine monocytic ehrlichiosis (CME)], and group H involved 20 healthy controls (negative for B. c. vogeli and E. canis). Solely dogs presenting uncomplicated babesiosis caused by B. c. vogeli were enrolled. Serum urea and serum creatinine (Cre) levels with serum Urea:Cre ratios were analyzed. Canine serum Cys-C was determined with a species-specific commercially available and validated ELISA assay as a reference. Mean serum Cys-C levels were 5.28 mg/L, 3.02 mg/L, and 2.30 mg/L for groups B, E and H, respectively. RF in uncomplicated CB caused by B. c. vogeli seems to be affected based on serum Cys-C concentrations. To the author's knowledge, this is the first study reporting that mean serum canine Cys-C levels in dogs with CME demonstrated no elevation. Serum canine Cys-C as a novel RF marker could be used for early detection of renal injury in both babesiosis and CME.Didem PEKMEZCIKerem URALNuran AYSULMurat GUZELGulay CIFTCISciendoarticlerenal functioncystatin-ccaninebabesia canis vogeliehrlichia canisVeterinary medicineSF600-1100ENActa Veterinaria, Vol 65, Iss 1, Pp 56-65 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal function cystatin-c canine babesia canis vogeli ehrlichia canis Veterinary medicine SF600-1100
spellingShingle	renal function cystatin-c canine babesia canis vogeli ehrlichia canis Veterinary medicine SF600-1100 Didem PEKMEZCI Kerem URAL Nuran AYSUL Murat GUZEL Gulay CIFTCI Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis
description	The purpose of the present study was to evaluate serum canine Cystatin-C (Cys-C) concentration for the prediction of renal function (RF) in dogs naturally infected with Babesia canis vogeli and Ehrlichia canis. A total of 46 dogs were enrolled into three groups. Group B included 16 dogs naturally infected with B. c. vogeli, group E 10 dogs naturally infected with E. canis [dogs diagnosed as canine monocytic ehrlichiosis (CME)], and group H involved 20 healthy controls (negative for B. c. vogeli and E. canis). Solely dogs presenting uncomplicated babesiosis caused by B. c. vogeli were enrolled. Serum urea and serum creatinine (Cre) levels with serum Urea:Cre ratios were analyzed. Canine serum Cys-C was determined with a species-specific commercially available and validated ELISA assay as a reference. Mean serum Cys-C levels were 5.28 mg/L, 3.02 mg/L, and 2.30 mg/L for groups B, E and H, respectively. RF in uncomplicated CB caused by B. c. vogeli seems to be affected based on serum Cys-C concentrations. To the author's knowledge, this is the first study reporting that mean serum canine Cys-C levels in dogs with CME demonstrated no elevation. Serum canine Cys-C as a novel RF marker could be used for early detection of renal injury in both babesiosis and CME.
format	article
author	Didem PEKMEZCI Kerem URAL Nuran AYSUL Murat GUZEL Gulay CIFTCI
author_facet	Didem PEKMEZCI Kerem URAL Nuran AYSUL Murat GUZEL Gulay CIFTCI
author_sort	Didem PEKMEZCI
title	Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis
title_short	Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis
title_full	Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis
title_fullStr	Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis
title_full_unstemmed	Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis
title_sort	assessment of renal function using canine cystatin-c levels in canine babesiosis and ehrlichiosis
publisher	Sciendo
publishDate	2015
url	https://doaj.org/article/7c1d05d68fa3450098eac3058be1b701
work_keys_str_mv	AT didempekmezci assessmentofrenalfunctionusingcaninecystatinclevelsincaninebabesiosisandehrlichiosis AT keremural assessmentofrenalfunctionusingcaninecystatinclevelsincaninebabesiosisandehrlichiosis AT nuranaysul assessmentofrenalfunctionusingcaninecystatinclevelsincaninebabesiosisandehrlichiosis AT muratguzel assessmentofrenalfunctionusingcaninecystatinclevelsincaninebabesiosisandehrlichiosis AT gulayciftci assessmentofrenalfunctionusingcaninecystatinclevelsincaninebabesiosisandehrlichiosis
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Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis

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