Resistance and Overcoming Resistance in Breast Cancer

Andrea Luque-Bolivar,1 Erika Pérez-Mora,1 Victoria Eugenia Villegas,2 Milena Rondón-Lagos1 1School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia; 2Biology Program, Faculty of Natural Sciences, Universidad...

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Autores principales:	Luque-Bolivar A, Pérez-Mora E, Villegas VE, Rondón-Lagos M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	breast cancer endocrine therapy chemotherapy resistance emerging treatments Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7c1dfba0549d44dc9fb86bbd1ba05417
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spelling	oai:doaj.org-article:7c1dfba0549d44dc9fb86bbd1ba054172021-12-02T11:38:21ZResistance and Overcoming Resistance in Breast Cancer1179-1314https://doaj.org/article/7c1dfba0549d44dc9fb86bbd1ba054172020-11-01T00:00:00Zhttps://www.dovepress.com/resistance-and-overcoming-resistance-in-breast-cancer-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Andrea Luque-Bolivar,1 Erika Pérez-Mora,1 Victoria Eugenia Villegas,2 Milena Rondón-Lagos1 1School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia; 2Biology Program, Faculty of Natural Sciences, Universidad del Rosario, Bogotá 111221, ColombiaCorrespondence: Victoria Eugenia VillegasBiology Program, Faculty of Natural Sciences, Universidad del Rosario, Bogotá 111221, ColombiaTel/Fax +57-1-297-0200 Ext 4029Email victoria.villegas@urosario.edu.coMilena Rondón-LagosSchool of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, ColombiaTel/Fax +57-8-7420-8263Email sandra.rondon01@uptc.edu.coAbstract: The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is the main cause of cancer-related death in women worldwide. One of the most significant clinical problems in the treatment of patients with BC is the development of therapeutic resistance. Therefore, elucidating the molecular mechanisms involved in drug resistance is critical. The therapeutic decision for the management of patients with BC is based not only on the assessment of prognostic factors but also on the evaluation of clinical and pathological parameters. Although this has been a successful approach, some patients relapse and/or eventually develop resistance to treatment. This review is focused on recent studies on the possible biological and molecular mechanisms involved in both response and resistance to treatment in BC. Additionally, emerging treatments that seek to overcome resistance and reduce side effects are also described. A greater understanding of the mechanisms of action of treatments used in BC might contribute not only to the enhancement of our understanding of the mechanisms involved in the development of resistance but also to the optimization of the existing treatment regimens.Keywords: breast cancer, endocrine therapy, chemotherapy, resistance, emerging treatmentsLuque-Bolivar APérez-Mora EVillegas VERondón-Lagos MDove Medical Pressarticlebreast cancerendocrine therapychemotherapyresistanceemerging treatmentsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 12, Pp 211-229 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer endocrine therapy chemotherapy resistance emerging treatments Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer endocrine therapy chemotherapy resistance emerging treatments Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Luque-Bolivar A Pérez-Mora E Villegas VE Rondón-Lagos M Resistance and Overcoming Resistance in Breast Cancer
description	Andrea Luque-Bolivar,1 Erika Pérez-Mora,1 Victoria Eugenia Villegas,2 Milena Rondón-Lagos1 1School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia; 2Biology Program, Faculty of Natural Sciences, Universidad del Rosario, Bogotá 111221, ColombiaCorrespondence: Victoria Eugenia VillegasBiology Program, Faculty of Natural Sciences, Universidad del Rosario, Bogotá 111221, ColombiaTel/Fax +57-1-297-0200 Ext 4029Email victoria.villegas@urosario.edu.coMilena Rondón-LagosSchool of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, ColombiaTel/Fax +57-8-7420-8263Email sandra.rondon01@uptc.edu.coAbstract: The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is the main cause of cancer-related death in women worldwide. One of the most significant clinical problems in the treatment of patients with BC is the development of therapeutic resistance. Therefore, elucidating the molecular mechanisms involved in drug resistance is critical. The therapeutic decision for the management of patients with BC is based not only on the assessment of prognostic factors but also on the evaluation of clinical and pathological parameters. Although this has been a successful approach, some patients relapse and/or eventually develop resistance to treatment. This review is focused on recent studies on the possible biological and molecular mechanisms involved in both response and resistance to treatment in BC. Additionally, emerging treatments that seek to overcome resistance and reduce side effects are also described. A greater understanding of the mechanisms of action of treatments used in BC might contribute not only to the enhancement of our understanding of the mechanisms involved in the development of resistance but also to the optimization of the existing treatment regimens.Keywords: breast cancer, endocrine therapy, chemotherapy, resistance, emerging treatments
format	article
author	Luque-Bolivar A Pérez-Mora E Villegas VE Rondón-Lagos M
author_facet	Luque-Bolivar A Pérez-Mora E Villegas VE Rondón-Lagos M
author_sort	Luque-Bolivar A
title	Resistance and Overcoming Resistance in Breast Cancer
title_short	Resistance and Overcoming Resistance in Breast Cancer
title_full	Resistance and Overcoming Resistance in Breast Cancer
title_fullStr	Resistance and Overcoming Resistance in Breast Cancer
title_full_unstemmed	Resistance and Overcoming Resistance in Breast Cancer
title_sort	resistance and overcoming resistance in breast cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7c1dfba0549d44dc9fb86bbd1ba05417
work_keys_str_mv	AT luquebolivara resistanceandovercomingresistanceinbreastcancer AT perezmorae resistanceandovercomingresistanceinbreastcancer AT villegasve resistanceandovercomingresistanceinbreastcancer AT rondonlagosm resistanceandovercomingresistanceinbreastcancer
_version_	1718395768140726272

Resistance and Overcoming Resistance in Breast Cancer

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