Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability ....

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Autores principales:	Demis Menolfi, Wenxia Jiang, Brian J. Lee, Tatiana Moiseeva, Zhengping Shao, Verna Estes, Mark G. Frattini, Christopher J. Bakkenist, Shan Zha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c2497d431244adcb615e18c3e661a2e
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spelling	oai:doaj.org-article:7c2497d431244adcb615e18c3e661a2e2021-12-02T17:31:29ZKinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA10.1038/s41467-018-07798-32041-1723https://doaj.org/article/7c2497d431244adcb615e18c3e661a2e2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07798-3https://doaj.org/toc/2041-1723ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability .Demis MenolfiWenxia JiangBrian J. LeeTatiana MoiseevaZhengping ShaoVerna EstesMark G. FrattiniChristopher J. BakkenistShan ZhaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Demis Menolfi Wenxia Jiang Brian J. Lee Tatiana Moiseeva Zhengping Shao Verna Estes Mark G. Frattini Christopher J. Bakkenist Shan Zha Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
description	ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability .
format	article
author	Demis Menolfi Wenxia Jiang Brian J. Lee Tatiana Moiseeva Zhengping Shao Verna Estes Mark G. Frattini Christopher J. Bakkenist Shan Zha
author_facet	Demis Menolfi Wenxia Jiang Brian J. Lee Tatiana Moiseeva Zhengping Shao Verna Estes Mark G. Frattini Christopher J. Bakkenist Shan Zha
author_sort	Demis Menolfi
title	Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
title_short	Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
title_full	Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
title_fullStr	Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
title_full_unstemmed	Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
title_sort	kinase-dead atr differs from atr loss by limiting the dynamic exchange of atr and rpa
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7c2497d431244adcb615e18c3e661a2e
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Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

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