Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability ....

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Autores principales: Demis Menolfi, Wenxia Jiang, Brian J. Lee, Tatiana Moiseeva, Zhengping Shao, Verna Estes, Mark G. Frattini, Christopher J. Bakkenist, Shan Zha
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/7c2497d431244adcb615e18c3e661a2e
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