Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase

rDNA repeats residing in the nucleolus must be released to the nucleoplasm to allow repair by homologous recombination. Here the authors reveal insights into the molecular mechanism proposing that phosphorylation and SUMOylation of the rDNA-tethering complex facilitate the nucleolar release of damag...

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Autores principales:	Matías Capella, Imke K. Mandemaker, Lucía Martín Caballero, Fabian den Brave, Boris Pfander, Andreas G. Ladurner, Stefan Jentsch, Sigurd Braun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c25cbe4fae14af59e6291014ce9f3bc
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spelling	oai:doaj.org-article:7c25cbe4fae14af59e6291014ce9f3bc2021-12-02T18:50:57ZNucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase10.1038/s41467-021-25205-22041-1723https://doaj.org/article/7c25cbe4fae14af59e6291014ce9f3bc2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25205-2https://doaj.org/toc/2041-1723rDNA repeats residing in the nucleolus must be released to the nucleoplasm to allow repair by homologous recombination. Here the authors reveal insights into the molecular mechanism proposing that phosphorylation and SUMOylation of the rDNA-tethering complex facilitate the nucleolar release of damaged repeats to maintain genome integrity.Matías CapellaImke K. MandemakerLucía Martín CaballeroFabian den BraveBoris PfanderAndreas G. LadurnerStefan JentschSigurd BraunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matías Capella Imke K. Mandemaker Lucía Martín Caballero Fabian den Brave Boris Pfander Andreas G. Ladurner Stefan Jentsch Sigurd Braun Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase
description	rDNA repeats residing in the nucleolus must be released to the nucleoplasm to allow repair by homologous recombination. Here the authors reveal insights into the molecular mechanism proposing that phosphorylation and SUMOylation of the rDNA-tethering complex facilitate the nucleolar release of damaged repeats to maintain genome integrity.
format	article
author	Matías Capella Imke K. Mandemaker Lucía Martín Caballero Fabian den Brave Boris Pfander Andreas G. Ladurner Stefan Jentsch Sigurd Braun
author_facet	Matías Capella Imke K. Mandemaker Lucía Martín Caballero Fabian den Brave Boris Pfander Andreas G. Ladurner Stefan Jentsch Sigurd Braun
author_sort	Matías Capella
title	Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase
title_short	Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase
title_full	Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase
title_fullStr	Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase
title_full_unstemmed	Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase
title_sort	nucleolar release of rdna repeats for repair involves sumo-mediated untethering by the cdc48/p97 segregase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c25cbe4fae14af59e6291014ce9f3bc
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Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase

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