Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer

Abstract The purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retr...

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Autores principales:	Jae-Hoon Lee, Soyoung Kim, Hye Sun Lee, Eun Jung Park, Seung Hyuk Baik, Tae Joo Jeon, Kang Young Lee, Young Hoon Ryu, Jeonghyun Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c271fe69f5b408babb18d68b8f6a0dd
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spelling	oai:doaj.org-article:7c271fe69f5b408babb18d68b8f6a0dd2021-11-08T10:50:57ZDifferent prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer10.1038/s41598-021-01086-92045-2322https://doaj.org/article/7c271fe69f5b408babb18d68b8f6a0dd2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01086-9https://doaj.org/toc/2045-2322Abstract The purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients.Jae-Hoon LeeSoyoung KimHye Sun LeeEun Jung ParkSeung Hyuk BaikTae Joo JeonKang Young LeeYoung Hoon RyuJeonghyun KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae-Hoon Lee Soyoung Kim Hye Sun Lee Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
description	Abstract The purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients.
format	article
author	Jae-Hoon Lee Soyoung Kim Hye Sun Lee Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang
author_facet	Jae-Hoon Lee Soyoung Kim Hye Sun Lee Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang
author_sort	Jae-Hoon Lee
title	Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
title_short	Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
title_full	Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
title_fullStr	Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
title_full_unstemmed	Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
title_sort	different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c271fe69f5b408babb18d68b8f6a0dd
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Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer

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