A human antibody against Zika virus crosslinks the E protein to prevent infection

The human monoclonal antibody ZIKV-117 has demonstrated therapeutic potential against Zika while showing no cross-reactivity to other flaviviruses. Here the authors present a cryo-EM structure of the ZIKV strain H/PF/2013 in complex with the ZIKV-117 Fab, shedding light on its neutralization mechani...

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Autores principales:	S. Saif Hasan, Andrew Miller, Gopal Sapparapu, Estefania Fernandez, Thomas Klose, Feng Long, Andrei Fokine, Jason C. Porta, Wen Jiang, Michael S. Diamond, James E. Crowe Jr., Richard J. Kuhn, Michael G. Rossmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c282344e221410e8459e2cb05b2a216
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spelling	oai:doaj.org-article:7c282344e221410e8459e2cb05b2a2162021-12-02T15:38:33ZA human antibody against Zika virus crosslinks the E protein to prevent infection10.1038/ncomms147222041-1723https://doaj.org/article/7c282344e221410e8459e2cb05b2a2162017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14722https://doaj.org/toc/2041-1723The human monoclonal antibody ZIKV-117 has demonstrated therapeutic potential against Zika while showing no cross-reactivity to other flaviviruses. Here the authors present a cryo-EM structure of the ZIKV strain H/PF/2013 in complex with the ZIKV-117 Fab, shedding light on its neutralization mechanism.S. Saif HasanAndrew MillerGopal SapparapuEstefania FernandezThomas KloseFeng LongAndrei FokineJason C. PortaWen JiangMichael S. DiamondJames E. Crowe Jr.Richard J. KuhnMichael G. RossmannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Saif Hasan Andrew Miller Gopal Sapparapu Estefania Fernandez Thomas Klose Feng Long Andrei Fokine Jason C. Porta Wen Jiang Michael S. Diamond James E. Crowe Jr. Richard J. Kuhn Michael G. Rossmann A human antibody against Zika virus crosslinks the E protein to prevent infection
description	The human monoclonal antibody ZIKV-117 has demonstrated therapeutic potential against Zika while showing no cross-reactivity to other flaviviruses. Here the authors present a cryo-EM structure of the ZIKV strain H/PF/2013 in complex with the ZIKV-117 Fab, shedding light on its neutralization mechanism.
format	article
author	S. Saif Hasan Andrew Miller Gopal Sapparapu Estefania Fernandez Thomas Klose Feng Long Andrei Fokine Jason C. Porta Wen Jiang Michael S. Diamond James E. Crowe Jr. Richard J. Kuhn Michael G. Rossmann
author_facet	S. Saif Hasan Andrew Miller Gopal Sapparapu Estefania Fernandez Thomas Klose Feng Long Andrei Fokine Jason C. Porta Wen Jiang Michael S. Diamond James E. Crowe Jr. Richard J. Kuhn Michael G. Rossmann
author_sort	S. Saif Hasan
title	A human antibody against Zika virus crosslinks the E protein to prevent infection
title_short	A human antibody against Zika virus crosslinks the E protein to prevent infection
title_full	A human antibody against Zika virus crosslinks the E protein to prevent infection
title_fullStr	A human antibody against Zika virus crosslinks the E protein to prevent infection
title_full_unstemmed	A human antibody against Zika virus crosslinks the E protein to prevent infection
title_sort	human antibody against zika virus crosslinks the e protein to prevent infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7c282344e221410e8459e2cb05b2a216
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A human antibody against Zika virus crosslinks the E protein to prevent infection

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