The five-year survival of gastric cancer patients with a focus on its prognostic factors

Introduction: Despite extensive advances in the early diagnosis and treatment of gastric cancer, it is still one of the most common causes of death worldwide. In addition to stage and recurrence, the degree of tumor differentiation affects the survival of patients. Objectives: The current study was...

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Autores principales:	Abdolhassan Talaiezadeh, Mahsa Noroozi, Pedram Nazari, Ali Ehsanpour
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2022
Materias:	gastric cancer overall survival surgery Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/7c298ae6567e485088cca2d7ece85dc1
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spelling	oai:doaj.org-article:7c298ae6567e485088cca2d7ece85dc12021-11-16T10:42:13ZThe five-year survival of gastric cancer patients with a focus on its prognostic factors2476-393410.34172/jpe.2022.06https://doaj.org/article/7c298ae6567e485088cca2d7ece85dc12022-01-01T00:00:00Zhttps://jprevepi.com/PDF/jpe-7-e06.pdfhttps://doaj.org/toc/2476-3934Introduction: Despite extensive advances in the early diagnosis and treatment of gastric cancer, it is still one of the most common causes of death worldwide. In addition to stage and recurrence, the degree of tumor differentiation affects the survival of patients. Objectives: The current study was conducted to investigate the prognostic factors and survival rate of patients with gastric cancer. Patients and Methods: The current prospective study was conducted on patients with gastric cancer from 2010 to 2017 in Imam Khomeini and Apadana hospitals in Ahvaz, Southwest of Iran. For each patient, curative (total or subtotal gastrectomy with D2 lymphadenectomy) or palliative surgery (partial gastrectomy and gastrojejunostomy) were carried out based on clinical indications. Then Cox model was used to analyze factors affecting survival and the Kaplan-Meier test was also utilized to analyze the five-year survival of patients with SPSS version 21. Results: Around 154 patients with gastric cancer, including 101 males (65.6%), with a mean age of 62.21±13.76 years, were studied. The two- and five-year overall survival (OS) of patients were 57.7% and 28.5%, respectively (median OS=28 m). Lower stage, well-differentiated tumors, absence of metastasis, lack of recurrence, receiving adjuvant chemotherapy and curative surgery were significantly associated with greater OS (P<0.05). Conclusion: OS rate of patients with gastric cancer undergoing surgery, especially in the ones with high-grade tumors, metastasis and recurrence, is relatively low, hence careful implementation of screening programs should be considered as the most important preventive strategy.Abdolhassan TalaiezadehMahsa NorooziPedram NazariAli EhsanpourSociety of Diabetic Nephropathy Preventionarticlegastric canceroverall survivalsurgerySpecialties of internal medicineRC581-951Infectious and parasitic diseasesRC109-216ENJournal of Preventive Epidemiology, Vol 7, Iss 1, Pp e06-e06 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer overall survival surgery Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
spellingShingle	gastric cancer overall survival surgery Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216 Abdolhassan Talaiezadeh Mahsa Noroozi Pedram Nazari Ali Ehsanpour The five-year survival of gastric cancer patients with a focus on its prognostic factors
description	Introduction: Despite extensive advances in the early diagnosis and treatment of gastric cancer, it is still one of the most common causes of death worldwide. In addition to stage and recurrence, the degree of tumor differentiation affects the survival of patients. Objectives: The current study was conducted to investigate the prognostic factors and survival rate of patients with gastric cancer. Patients and Methods: The current prospective study was conducted on patients with gastric cancer from 2010 to 2017 in Imam Khomeini and Apadana hospitals in Ahvaz, Southwest of Iran. For each patient, curative (total or subtotal gastrectomy with D2 lymphadenectomy) or palliative surgery (partial gastrectomy and gastrojejunostomy) were carried out based on clinical indications. Then Cox model was used to analyze factors affecting survival and the Kaplan-Meier test was also utilized to analyze the five-year survival of patients with SPSS version 21. Results: Around 154 patients with gastric cancer, including 101 males (65.6%), with a mean age of 62.21±13.76 years, were studied. The two- and five-year overall survival (OS) of patients were 57.7% and 28.5%, respectively (median OS=28 m). Lower stage, well-differentiated tumors, absence of metastasis, lack of recurrence, receiving adjuvant chemotherapy and curative surgery were significantly associated with greater OS (P<0.05). Conclusion: OS rate of patients with gastric cancer undergoing surgery, especially in the ones with high-grade tumors, metastasis and recurrence, is relatively low, hence careful implementation of screening programs should be considered as the most important preventive strategy.
format	article
author	Abdolhassan Talaiezadeh Mahsa Noroozi Pedram Nazari Ali Ehsanpour
author_facet	Abdolhassan Talaiezadeh Mahsa Noroozi Pedram Nazari Ali Ehsanpour
author_sort	Abdolhassan Talaiezadeh
title	The five-year survival of gastric cancer patients with a focus on its prognostic factors
title_short	The five-year survival of gastric cancer patients with a focus on its prognostic factors
title_full	The five-year survival of gastric cancer patients with a focus on its prognostic factors
title_fullStr	The five-year survival of gastric cancer patients with a focus on its prognostic factors
title_full_unstemmed	The five-year survival of gastric cancer patients with a focus on its prognostic factors
title_sort	five-year survival of gastric cancer patients with a focus on its prognostic factors
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2022
url	https://doaj.org/article/7c298ae6567e485088cca2d7ece85dc1
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The five-year survival of gastric cancer patients with a focus on its prognostic factors

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