Absolute Structure Determination and Kv1.5 Ion Channel Inhibition Activities of New Debromoaplysiatoxin Analogues
Potassium channel Kv1.5 has been considered a key target for new treatments of atrial tachyarrhythmias, with few side effects. Four new debromoaplysiatoxin analogues with a 6/6/12 fused ring system were isolated from marine cyanobacterium <i>Lyngbya</i> sp. Their planar structures were e...
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Autores principales: | Sicheng Shen, Weiping Wang, Zijun Chen, Huihui Zhang, Yuchun Yang, Xiaoliang Wang, Peng Fu, Bingnan Han |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/7c31b6140be4450a9a86d853edfdb956 |
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