Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly...

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Autores principales:	Vincenzo Bronte, Sven Brandau, Shu-Hsia Chen, Mario P. Colombo, Alan B. Frey, Tim F. Greten, Susanna Mandruzzato, Peter J. Murray, Augusto Ochoa, Suzanne Ostrand-Rosenberg, Paulo C. Rodriguez, Antonio Sica, Viktor Umansky, Robert H. Vonderheide, Dmitry I. Gabrilovich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c32c093ca484097b5efdfd00dee7e64
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spelling	oai:doaj.org-article:7c32c093ca484097b5efdfd00dee7e642021-12-02T15:35:22ZRecommendations for myeloid-derived suppressor cell nomenclature and characterization standards10.1038/ncomms121502041-1723https://doaj.org/article/7c32c093ca484097b5efdfd00dee7e642016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12150https://doaj.org/toc/2041-1723Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.Vincenzo BronteSven BrandauShu-Hsia ChenMario P. ColomboAlan B. FreyTim F. GretenSusanna MandruzzatoPeter J. MurrayAugusto OchoaSuzanne Ostrand-RosenbergPaulo C. RodriguezAntonio SicaViktor UmanskyRobert H. VonderheideDmitry I. GabrilovichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincenzo Bronte Sven Brandau Shu-Hsia Chen Mario P. Colombo Alan B. Frey Tim F. Greten Susanna Mandruzzato Peter J. Murray Augusto Ochoa Suzanne Ostrand-Rosenberg Paulo C. Rodriguez Antonio Sica Viktor Umansky Robert H. Vonderheide Dmitry I. Gabrilovich Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
description	Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.
format	article
author	Vincenzo Bronte Sven Brandau Shu-Hsia Chen Mario P. Colombo Alan B. Frey Tim F. Greten Susanna Mandruzzato Peter J. Murray Augusto Ochoa Suzanne Ostrand-Rosenberg Paulo C. Rodriguez Antonio Sica Viktor Umansky Robert H. Vonderheide Dmitry I. Gabrilovich
author_facet	Vincenzo Bronte Sven Brandau Shu-Hsia Chen Mario P. Colombo Alan B. Frey Tim F. Greten Susanna Mandruzzato Peter J. Murray Augusto Ochoa Suzanne Ostrand-Rosenberg Paulo C. Rodriguez Antonio Sica Viktor Umansky Robert H. Vonderheide Dmitry I. Gabrilovich
author_sort	Vincenzo Bronte
title	Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_short	Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_full	Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_fullStr	Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_full_unstemmed	Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_sort	recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7c32c093ca484097b5efdfd00dee7e64
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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

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