PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS

The article presents the results of the research of CD3/CD28-induced production of interleukin-2 by blood lymphocytes in vitro as well as subpopulation composition of peripheral blood T-lymphocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. We detected the decrease in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. A. Koshkina, V. V. Novitskij, O. I. Urazova, I. E. Esimova, R. R. Hasanova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	pulmonary tuberculosis t-lymphocytes interleukin-2 intercellular cooperation Science Q
Acceso en línea:	https://doaj.org/article/7c363fae98314423a12311264c1119a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c363fae98314423a12311264c1119a4
record_format	dspace
spelling	oai:doaj.org-article:7c363fae98314423a12311264c1119a42021-11-23T06:14:19ZPECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS2541-94202587-9596https://doaj.org/article/7c363fae98314423a12311264c1119a42012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/893https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the results of the research of CD3/CD28-induced production of interleukin-2 by blood lymphocytes in vitro as well as subpopulation composition of peripheral blood T-lymphocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. We detected the decrease in the total amount of CD3-positive cells and suppression of IL-2- secretion during CD3/CD28-induction of lymphocytes, which was most expressed in a disseminated form of drug-resistant TB. We also demonstrated the reduction in the percentage value of CD3+CD28+IL-2+ and CD3+CD28+IL-2- cells in patients with pulmonary TB against the background of the increase in the percentage value of CD3+CD28-IL-2-. Besides, it was also shown that the detected changes are unidirectional, don't depend on a clinical form of TB and are maximally manifested in patients with a drug resistant variant of the TB process.A. A. KoshkinaV. V. NovitskijO. I. UrazovaI. E. EsimovaR. R. HasanovaScientific Сentre for Family Health and Human Reproduction Problemsarticlepulmonary tuberculosist-lymphocytesinterleukin-2intercellular cooperationScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 92-95 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	pulmonary tuberculosis t-lymphocytes interleukin-2 intercellular cooperation Science Q
spellingShingle	pulmonary tuberculosis t-lymphocytes interleukin-2 intercellular cooperation Science Q A. A. Koshkina V. V. Novitskij O. I. Urazova I. E. Esimova R. R. Hasanova PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
description	The article presents the results of the research of CD3/CD28-induced production of interleukin-2 by blood lymphocytes in vitro as well as subpopulation composition of peripheral blood T-lymphocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. We detected the decrease in the total amount of CD3-positive cells and suppression of IL-2- secretion during CD3/CD28-induction of lymphocytes, which was most expressed in a disseminated form of drug-resistant TB. We also demonstrated the reduction in the percentage value of CD3+CD28+IL-2+ and CD3+CD28+IL-2- cells in patients with pulmonary TB against the background of the increase in the percentage value of CD3+CD28-IL-2-. Besides, it was also shown that the detected changes are unidirectional, don't depend on a clinical form of TB and are maximally manifested in patients with a drug resistant variant of the TB process.
format	article
author	A. A. Koshkina V. V. Novitskij O. I. Urazova I. E. Esimova R. R. Hasanova
author_facet	A. A. Koshkina V. V. Novitskij O. I. Urazova I. E. Esimova R. R. Hasanova
author_sort	A. A. Koshkina
title	PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_short	PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_full	PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_fullStr	PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_full_unstemmed	PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_sort	peculiarities of cd3/cd28-induced secretion of interleukin-2 and subpopulation composition of t-lymphocytes in patients with pulmonary tuberculosis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/7c363fae98314423a12311264c1119a4
work_keys_str_mv	AT aakoshkina peculiaritiesofcd3cd28inducedsecretionofinterleukin2andsubpopulationcompositionoftlymphocytesinpatientswithpulmonarytuberculosis AT vvnovitskij peculiaritiesofcd3cd28inducedsecretionofinterleukin2andsubpopulationcompositionoftlymphocytesinpatientswithpulmonarytuberculosis AT oiurazova peculiaritiesofcd3cd28inducedsecretionofinterleukin2andsubpopulationcompositionoftlymphocytesinpatientswithpulmonarytuberculosis AT ieesimova peculiaritiesofcd3cd28inducedsecretionofinterleukin2andsubpopulationcompositionoftlymphocytesinpatientswithpulmonarytuberculosis AT rrhasanova peculiaritiesofcd3cd28inducedsecretionofinterleukin2andsubpopulationcompositionoftlymphocytesinpatientswithpulmonarytuberculosis
_version_	1718417327636086784

PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS

Ejemplares similares