Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review

Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored the efficacy and safety of applying chlorpromazine on PMC pat...

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Autores principales:	James Jiqi Wang, Zuowen He, Yan Yang, Bo Yu, Hong Wang, Hu Ding, Guanglin Cui, Luyun Wang, Dao Wen Wang, Jiangang Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pheochromocytoma multisystem crisis chlorpromazine pheochromocytoma case series hypertension catecholamine Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/7c374a359853498c8278103b782354eb
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spelling	oai:doaj.org-article:7c374a359853498c8278103b782354eb2021-11-22T06:07:56ZChlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review2297-055X10.3389/fcvm.2021.762371https://doaj.org/article/7c374a359853498c8278103b782354eb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.762371/fullhttps://doaj.org/toc/2297-055XPheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored the efficacy and safety of applying chlorpromazine on PMC patients. The study included seven patients (median age, 42 years; range, 14–57 years) diagnosed with pheochromocytoma. Four consecutive PMC patients were admitted to our critical care unit between 2016 and 2020 due to abdominal or waist pain, nausea, and vomiting. Their blood pressure (BP) fluctuated between 200–330/120–200 and 40–70/30–50 mmHg. Chlorpromazine (25 or 50 mg) was injected intramuscularly, followed by continuous intravenous infusion (2–8 mg/h). The patients' BP decreased to 100–150/60–100 mmHg within 1–3 h and stabilized within 3–5 days. Two weeks later, surgical tumor resection was successfully performed in all four patients. Similar clinical outcomes were also obtained in three patients with sporadic PMC reported in the literature who received chlorpromazine treatment, which reduced their BP readings from >200/100 mmHg to 120/70 mmHg. Our observations, combined with sporadic reports, showed that chlorpromazine efficiently controlled PMC. Thus, future studies on the use of chlorpromazine are warranted.James Jiqi WangJames Jiqi WangZuowen HeZuowen HeYan YangBo YuBo YuHong WangHong WangHu DingHu DingGuanglin CuiGuanglin CuiLuyun WangLuyun WangDao Wen WangDao Wen WangJiangang JiangJiangang JiangFrontiers Media S.A.articlepheochromocytoma multisystem crisischlorpromazinepheochromocytomacase serieshypertensioncatecholamineDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pheochromocytoma multisystem crisis chlorpromazine pheochromocytoma case series hypertension catecholamine Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	pheochromocytoma multisystem crisis chlorpromazine pheochromocytoma case series hypertension catecholamine Diseases of the circulatory (Cardiovascular) system RC666-701 James Jiqi Wang James Jiqi Wang Zuowen He Zuowen He Yan Yang Bo Yu Bo Yu Hong Wang Hong Wang Hu Ding Hu Ding Guanglin Cui Guanglin Cui Luyun Wang Luyun Wang Dao Wen Wang Dao Wen Wang Jiangang Jiang Jiangang Jiang Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
description	Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored the efficacy and safety of applying chlorpromazine on PMC patients. The study included seven patients (median age, 42 years; range, 14–57 years) diagnosed with pheochromocytoma. Four consecutive PMC patients were admitted to our critical care unit between 2016 and 2020 due to abdominal or waist pain, nausea, and vomiting. Their blood pressure (BP) fluctuated between 200–330/120–200 and 40–70/30–50 mmHg. Chlorpromazine (25 or 50 mg) was injected intramuscularly, followed by continuous intravenous infusion (2–8 mg/h). The patients' BP decreased to 100–150/60–100 mmHg within 1–3 h and stabilized within 3–5 days. Two weeks later, surgical tumor resection was successfully performed in all four patients. Similar clinical outcomes were also obtained in three patients with sporadic PMC reported in the literature who received chlorpromazine treatment, which reduced their BP readings from >200/100 mmHg to 120/70 mmHg. Our observations, combined with sporadic reports, showed that chlorpromazine efficiently controlled PMC. Thus, future studies on the use of chlorpromazine are warranted.
format	article
author	James Jiqi Wang James Jiqi Wang Zuowen He Zuowen He Yan Yang Bo Yu Bo Yu Hong Wang Hong Wang Hu Ding Hu Ding Guanglin Cui Guanglin Cui Luyun Wang Luyun Wang Dao Wen Wang Dao Wen Wang Jiangang Jiang Jiangang Jiang
author_facet	James Jiqi Wang James Jiqi Wang Zuowen He Zuowen He Yan Yang Bo Yu Bo Yu Hong Wang Hong Wang Hu Ding Hu Ding Guanglin Cui Guanglin Cui Luyun Wang Luyun Wang Dao Wen Wang Dao Wen Wang Jiangang Jiang Jiangang Jiang
author_sort	James Jiqi Wang
title	Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_short	Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_full	Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_fullStr	Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_full_unstemmed	Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_sort	chlorpromazine efficiently treats the crisis of pheochromocytoma: four case reports and literature review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7c374a359853498c8278103b782354eb
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Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review

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