In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study

Background: Acquired immune deficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV) infection, is a serious public health issue. This study investigated the correlated factors and possible changing trend of in-hospital death in patients diagnosed with HIV in the past decade in our h...

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Autores principales:	Cheng Bo Li, Ying Zhou, Yu Wang, Sheng Liu, Wen Wang, Xu Lu, Cui Ming Sun, Pei Liu, Qing-Hai Hu, Ying Wen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acquired immune deficiency syndrome in-hospital mortality antiretroviral therapy intensified medical care strategy cross-sectional study Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/7c396c98cd014c83aba7547e62fc4b5c
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spelling	oai:doaj.org-article:7c396c98cd014c83aba7547e62fc4b5c2021-12-01T16:25:43ZIn-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study2296-256510.3389/fpubh.2021.774614https://doaj.org/article/7c396c98cd014c83aba7547e62fc4b5c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.774614/fullhttps://doaj.org/toc/2296-2565Background: Acquired immune deficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV) infection, is a serious public health issue. This study investigated the correlated factors and possible changing trend of in-hospital death in patients diagnosed with HIV in the past decade in our hospital.Methods: We retrospectively collected data of firstly hospitalized patients with HIV in the Department of Infectious Disease in the First Affiliated Hospital of China Medical University from January 1, 2010 to December 31, 2019, and compared various factors that correlated with in-hospital death, including age, sex, opportunistic infections, and antiretroviral therapy (ART) status. Cox regression analysis was used to identify the risk factors for death.Results: In total, 711 patients were recruited for this study, and 62 patients died in the hospital. The in-hospital mortality rate was 8.72%. Tuberculosis (TB), malignancies, and thrombocytopenia were associated with mortality. Antiviral treatment before admission was found to be a protective factor. There was a declining trend in in-hospital mortality from 19.2% in 2010 to 6.3% in 2019 (linear-by-linear association test, p < 0.001), partly due to intensified medical care strategy.Conclusions: Till date, AIDS-defining illnesses remain the major cause of hospital admission and in-hospital mortality. TB and malignancies were correlated risk factors for in-hospital mortality. ART before admission was found to be beneficial, and considering the decreasing rate of in-hospital mortality, the implementation of intensified medical care strategy requires further effort.Cheng Bo LiYing ZhouYu WangSheng LiuWen WangXu LuCui Ming SunPei LiuQing-Hai HuYing WenFrontiers Media S.A.articleacquired immune deficiency syndromein-hospital mortalityantiretroviral therapyintensified medical care strategycross-sectional studyPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acquired immune deficiency syndrome in-hospital mortality antiretroviral therapy intensified medical care strategy cross-sectional study Public aspects of medicine RA1-1270
spellingShingle	acquired immune deficiency syndrome in-hospital mortality antiretroviral therapy intensified medical care strategy cross-sectional study Public aspects of medicine RA1-1270 Cheng Bo Li Ying Zhou Yu Wang Sheng Liu Wen Wang Xu Lu Cui Ming Sun Pei Liu Qing-Hai Hu Ying Wen In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study
description	Background: Acquired immune deficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV) infection, is a serious public health issue. This study investigated the correlated factors and possible changing trend of in-hospital death in patients diagnosed with HIV in the past decade in our hospital.Methods: We retrospectively collected data of firstly hospitalized patients with HIV in the Department of Infectious Disease in the First Affiliated Hospital of China Medical University from January 1, 2010 to December 31, 2019, and compared various factors that correlated with in-hospital death, including age, sex, opportunistic infections, and antiretroviral therapy (ART) status. Cox regression analysis was used to identify the risk factors for death.Results: In total, 711 patients were recruited for this study, and 62 patients died in the hospital. The in-hospital mortality rate was 8.72%. Tuberculosis (TB), malignancies, and thrombocytopenia were associated with mortality. Antiviral treatment before admission was found to be a protective factor. There was a declining trend in in-hospital mortality from 19.2% in 2010 to 6.3% in 2019 (linear-by-linear association test, p < 0.001), partly due to intensified medical care strategy.Conclusions: Till date, AIDS-defining illnesses remain the major cause of hospital admission and in-hospital mortality. TB and malignancies were correlated risk factors for in-hospital mortality. ART before admission was found to be beneficial, and considering the decreasing rate of in-hospital mortality, the implementation of intensified medical care strategy requires further effort.
format	article
author	Cheng Bo Li Ying Zhou Yu Wang Sheng Liu Wen Wang Xu Lu Cui Ming Sun Pei Liu Qing-Hai Hu Ying Wen
author_facet	Cheng Bo Li Ying Zhou Yu Wang Sheng Liu Wen Wang Xu Lu Cui Ming Sun Pei Liu Qing-Hai Hu Ying Wen
author_sort	Cheng Bo Li
title	In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study
title_short	In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study
title_full	In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study
title_fullStr	In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study
title_full_unstemmed	In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study
title_sort	in-hospital mortality and causes of death in people diagnosed with hiv in a general hospital in shenyang, china: a cross-sectional study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7c396c98cd014c83aba7547e62fc4b5c
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In-hospital Mortality and Causes of Death in People Diagnosed With HIV in a General Hospital in Shenyang, China: A Cross-Sectional Study

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