The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease

Despite many years of research, radical treatment of Alzheimer's disease (AD) has still not been found. Amyloid-β (Aβ) peptide is known to play an important role in the pathogenesis of this disease. AD is characterized by three main changes occurring in the central nervous system: (1) Aβ plaque...

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Autores principales:	Asli Aykac, Ahmet Özer Sehirli
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	abc transporters alzheimer's diseases amyloid-β p-glycoprotein multidrug resistance protein 1 Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7c3a21cc02674b059b83186f8ced0d41
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spelling	oai:doaj.org-article:7c3a21cc02674b059b83186f8ced0d412021-12-01T23:41:03ZThe Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease2699-940410.1055/s-0041-1735541https://doaj.org/article/7c3a21cc02674b059b83186f8ced0d412021-09-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1735541https://doaj.org/toc/2699-9404Despite many years of research, radical treatment of Alzheimer's disease (AD) has still not been found. Amyloid-β (Aβ) peptide is known to play an important role in the pathogenesis of this disease. AD is characterized by three main changes occurring in the central nervous system: (1) Aβ plaque accumulation that prevents synaptic communication, (2) the accumulation of hyperphosphorylated tau proteins that inhibit the transport of molecules inside neurons, and (3) neuronal cell loss of the limbic system. Mechanisms leading to Aβ accumulation in AD are excessive Aβ production as a result of mutations in amyloid precursor protein or genes, and impairment of clearance of Aβ due to changes in Aβ aggregation properties and/or Aβ removal processes. Human ATP-binding cassette (ABC) transporters are expressed in astrocyte, microglia, neuron, brain capillary endothelial cell, choroid plexus, choroid plexus epithelial cell, and ventricular ependymal cell. ABC transporters have essential detoxification and neuroprotective roles in the brain. The expression and functional changes in ABC transporters contribute to the accumulation of Aβ peptide. In conclusion, the review was aimed to summarize and highlight accumulated evidence in the literature focusing on the changing functions of human ABC transporter members, in AD pathogenesis and progression.Asli AykacAhmet Özer SehirliGeorg Thieme Verlag KGarticleabc transportersalzheimer's diseasesamyloid-βp-glycoproteinmultidrug resistance protein 1GeneticsQH426-470Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENGlobal Medical Genetics, Vol 08, Iss 04, Pp 149-155 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	abc transporters alzheimer's diseases amyloid-β p-glycoprotein multidrug resistance protein 1 Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	abc transporters alzheimer's diseases amyloid-β p-glycoprotein multidrug resistance protein 1 Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Asli Aykac Ahmet Özer Sehirli The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
description	Despite many years of research, radical treatment of Alzheimer's disease (AD) has still not been found. Amyloid-β (Aβ) peptide is known to play an important role in the pathogenesis of this disease. AD is characterized by three main changes occurring in the central nervous system: (1) Aβ plaque accumulation that prevents synaptic communication, (2) the accumulation of hyperphosphorylated tau proteins that inhibit the transport of molecules inside neurons, and (3) neuronal cell loss of the limbic system. Mechanisms leading to Aβ accumulation in AD are excessive Aβ production as a result of mutations in amyloid precursor protein or genes, and impairment of clearance of Aβ due to changes in Aβ aggregation properties and/or Aβ removal processes. Human ATP-binding cassette (ABC) transporters are expressed in astrocyte, microglia, neuron, brain capillary endothelial cell, choroid plexus, choroid plexus epithelial cell, and ventricular ependymal cell. ABC transporters have essential detoxification and neuroprotective roles in the brain. The expression and functional changes in ABC transporters contribute to the accumulation of Aβ peptide. In conclusion, the review was aimed to summarize and highlight accumulated evidence in the literature focusing on the changing functions of human ABC transporter members, in AD pathogenesis and progression.
format	article
author	Asli Aykac Ahmet Özer Sehirli
author_facet	Asli Aykac Ahmet Özer Sehirli
author_sort	Asli Aykac
title	The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
title_short	The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
title_full	The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
title_fullStr	The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
title_full_unstemmed	The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
title_sort	function and expression of atp-binding cassette transporters proteins in the alzheimer's disease
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/7c3a21cc02674b059b83186f8ced0d41
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The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease

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