Angiogenesis as an adaptive mechanism in ischemia

The article is devoted to angiogenesis as one of the ways to increase the stability of the ischemic tissue. It is shown that the reduction in ischemic tissue damage is based on four basic processes - vasculogenesis of endothelial progenitor cells, angiogenesis and arteriogenesis with the growth and...

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Autores principales:	M. G. Shurygin, I. A. Shurygina, N. N. Dremina, O. V. Kanya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	ischemia angiogenesis growth factors pluripotent cells Science Q
Acceso en línea:	https://doaj.org/article/7c3b80623533459eb32d262244704335
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spelling	oai:doaj.org-article:7c3b80623533459eb32d2622447043352021-11-23T06:14:29ZAngiogenesis as an adaptive mechanism in ischemia2541-94202587-9596https://doaj.org/article/7c3b80623533459eb32d2622447043352013-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1671https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article is devoted to angiogenesis as one of the ways to increase the stability of the ischemic tissue. It is shown that the reduction in ischemic tissue damage is based on four basic processes - vasculogenesis of endothelial progenitor cells, angiogenesis and arteriogenesis with the growth and subsequent stabilization of the outgrowths of mural cells and the growth of collaterals (expansive growth of pre-existing vessels). However, despite the great progress in the understanding of ischemia-induced angiogenesis, and a lot of positive results from its stimulation using the disclosed arrangements natural response to the reduction of tissue perfusion is still an unsolved problem is the practical use of this knowledge to improve the metabolic processes of organs and tissues with compromised vascular bed. The effect of a variety of recombinant growth factors is not enough long-term, and besides, is not without serious side effects. From this perspective, the greatest opportunities is the development of techniques using natural pool of pluripotent cells with high angiogenic potential.M. G. ShuryginI. A. ShuryginaN. N. DreminaO. V. KanyaScientific Сentre for Family Health and Human Reproduction Problemsarticleischemiaangiogenesisgrowth factorspluripotent cellsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 192-195 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	ischemia angiogenesis growth factors pluripotent cells Science Q
spellingShingle	ischemia angiogenesis growth factors pluripotent cells Science Q M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya Angiogenesis as an adaptive mechanism in ischemia
description	The article is devoted to angiogenesis as one of the ways to increase the stability of the ischemic tissue. It is shown that the reduction in ischemic tissue damage is based on four basic processes - vasculogenesis of endothelial progenitor cells, angiogenesis and arteriogenesis with the growth and subsequent stabilization of the outgrowths of mural cells and the growth of collaterals (expansive growth of pre-existing vessels). However, despite the great progress in the understanding of ischemia-induced angiogenesis, and a lot of positive results from its stimulation using the disclosed arrangements natural response to the reduction of tissue perfusion is still an unsolved problem is the practical use of this knowledge to improve the metabolic processes of organs and tissues with compromised vascular bed. The effect of a variety of recombinant growth factors is not enough long-term, and besides, is not without serious side effects. From this perspective, the greatest opportunities is the development of techniques using natural pool of pluripotent cells with high angiogenic potential.
format	article
author	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_facet	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_sort	M. G. Shurygin
title	Angiogenesis as an adaptive mechanism in ischemia
title_short	Angiogenesis as an adaptive mechanism in ischemia
title_full	Angiogenesis as an adaptive mechanism in ischemia
title_fullStr	Angiogenesis as an adaptive mechanism in ischemia
title_full_unstemmed	Angiogenesis as an adaptive mechanism in ischemia
title_sort	angiogenesis as an adaptive mechanism in ischemia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/7c3b80623533459eb32d262244704335
work_keys_str_mv	AT mgshurygin angiogenesisasanadaptivemechanisminischemia AT iashurygina angiogenesisasanadaptivemechanisminischemia AT nndremina angiogenesisasanadaptivemechanisminischemia AT ovkanya angiogenesisasanadaptivemechanisminischemia
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Angiogenesis as an adaptive mechanism in ischemia

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