Identification of a new regulation pathway of EGFR and E-cadherin dynamics

Abstract E-cadherin and EGFR are known to be closely associated hence regulating differentiation and proliferation notably in epithelia. We have previously shown that galectin-7 binds to E-cadherin and favors its retention at the plasma membrane. In this study, we shed in light that galectin-7 estab...

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Autores principales:	Veronique Proux-Gillardeaux, Tamara Advedissian, Charlotte Perin, Jean-Christophe Gelly, Mireille Viguier, Frederique Deshayes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c3d9230af46457dbd7fc0c4ed96b167
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spelling	oai:doaj.org-article:7c3d9230af46457dbd7fc0c4ed96b1672021-11-28T12:20:01ZIdentification of a new regulation pathway of EGFR and E-cadherin dynamics10.1038/s41598-021-02042-32045-2322https://doaj.org/article/7c3d9230af46457dbd7fc0c4ed96b1672021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02042-3https://doaj.org/toc/2045-2322Abstract E-cadherin and EGFR are known to be closely associated hence regulating differentiation and proliferation notably in epithelia. We have previously shown that galectin-7 binds to E-cadherin and favors its retention at the plasma membrane. In this study, we shed in light that galectin-7 establishes a physical link between E-cadherin and EGFR. Indeed, our results demonstrate that galectin-7 also binds to EGFR, but unlike the binding to E-cadherin this binding is sugar dependent. The establishment of E-cadherin/EGFR complex and the binding of galectin-7 to EGFR thus lead to a regulation of its signaling and intracellular trafficking allowing cell proliferation and migration control. In vivo observations further support these results since an epidermal thickening is observed in galectin-7 deficient mice. This study therefore reveals that galectin-7 controls epidermal homeostasis through the regulation of E-cadherin/EGFR balance.Veronique Proux-GillardeauxTamara AdvedissianCharlotte PerinJean-Christophe GellyMireille ViguierFrederique DeshayesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Veronique Proux-Gillardeaux Tamara Advedissian Charlotte Perin Jean-Christophe Gelly Mireille Viguier Frederique Deshayes Identification of a new regulation pathway of EGFR and E-cadherin dynamics
description	Abstract E-cadherin and EGFR are known to be closely associated hence regulating differentiation and proliferation notably in epithelia. We have previously shown that galectin-7 binds to E-cadherin and favors its retention at the plasma membrane. In this study, we shed in light that galectin-7 establishes a physical link between E-cadherin and EGFR. Indeed, our results demonstrate that galectin-7 also binds to EGFR, but unlike the binding to E-cadherin this binding is sugar dependent. The establishment of E-cadherin/EGFR complex and the binding of galectin-7 to EGFR thus lead to a regulation of its signaling and intracellular trafficking allowing cell proliferation and migration control. In vivo observations further support these results since an epidermal thickening is observed in galectin-7 deficient mice. This study therefore reveals that galectin-7 controls epidermal homeostasis through the regulation of E-cadherin/EGFR balance.
format	article
author	Veronique Proux-Gillardeaux Tamara Advedissian Charlotte Perin Jean-Christophe Gelly Mireille Viguier Frederique Deshayes
author_facet	Veronique Proux-Gillardeaux Tamara Advedissian Charlotte Perin Jean-Christophe Gelly Mireille Viguier Frederique Deshayes
author_sort	Veronique Proux-Gillardeaux
title	Identification of a new regulation pathway of EGFR and E-cadherin dynamics
title_short	Identification of a new regulation pathway of EGFR and E-cadherin dynamics
title_full	Identification of a new regulation pathway of EGFR and E-cadherin dynamics
title_fullStr	Identification of a new regulation pathway of EGFR and E-cadherin dynamics
title_full_unstemmed	Identification of a new regulation pathway of EGFR and E-cadherin dynamics
title_sort	identification of a new regulation pathway of egfr and e-cadherin dynamics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c3d9230af46457dbd7fc0c4ed96b167
work_keys_str_mv	AT veroniqueprouxgillardeaux identificationofanewregulationpathwayofegfrandecadherindynamics AT tamaraadvedissian identificationofanewregulationpathwayofegfrandecadherindynamics AT charlotteperin identificationofanewregulationpathwayofegfrandecadherindynamics AT jeanchristophegelly identificationofanewregulationpathwayofegfrandecadherindynamics AT mireilleviguier identificationofanewregulationpathwayofegfrandecadherindynamics AT frederiquedeshayes identificationofanewregulationpathwayofegfrandecadherindynamics
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Identification of a new regulation pathway of EGFR and E-cadherin dynamics

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