New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell

Soheila Kashanian1, Abbas Hemati Azandaryani1, Katayoun Derakhshandeh2,3 1School of Chemistry, Nanoscience and Nanotechnology Research Center and Sensor and Biosensor Research Center, Razi University, 2Department of Pharmaceutics, Kermanshah University of Medical Sciences, 3Nanoscience and Technolog...

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Autores principales:	Derakhshandeh K, Hemati Azandaryani A, Kashanian S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7c3e0ee26491484eb89e24d32c9b798a
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spelling	oai:doaj.org-article:7c3e0ee26491484eb89e24d32c9b798a2021-12-02T06:38:06ZNew surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell1176-91141178-2013https://doaj.org/article/7c3e0ee26491484eb89e24d32c9b798a2011-11-01T00:00:00Zhttp://www.dovepress.com/new-surface-modified-solid-lipid-nanoparticles-using-n-glutaryl-phosph-a8575https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Soheila Kashanian1, Abbas Hemati Azandaryani1, Katayoun Derakhshandeh2,3 1School of Chemistry, Nanoscience and Nanotechnology Research Center and Sensor and Biosensor Research Center, Razi University, 2Department of Pharmaceutics, Kermanshah University of Medical Sciences, 3Nanoscience and Technology Research Center School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran Background: Solid lipid nanoparticles (SLNs) are colloidal carrier systems which provide controlled-release profiles for many substances. In this study, we prepared aqueous dispersions of lipid nanoparticles using a modified, pH-sensitive derivative of phosphatidylethanolamine. Methods: SLNs were prepared using polysorbate 80 as the surfactant and tripalmitin glyceride and N-glutaryl phosphatidylethanolamine as the lipid components. Particle size, polydispersity index, and zeta potential were examined by photon correlation spectroscopy. Morphological evaluation was performed using scanning electron microscopy, atomic force microscopy, and differential scanning calorimetry. Results: Photon correlation spectroscopy revealed a particle hydrodynamic diameter of 165.8 nm and zeta potential of &ndash;41.6.0 mV for the drug-loaded nanoparticles. Atomic force microscopy investigation showed the nanoparticles to be 50&ndash;600 nm in length and 66.5 nm in height. Differential scanning calorimetry indicated that the majority of SLNs possessed less ordered arrangements of crystals compared with corresponding bulk lipids, which is favorable for improving drug-loading capacity. Drug-loading capacity and drug entrapment efficiency values for the SLNs were 25.32% and 94.32%, respectively. Conclusion: The SLNs prepared in this study were able to control the release of triamcinolone acetonide under acidic conditions. Keywords: solid lipid nanoparticles, high-shear homogenization, triamcinolone acetonide, tripalmitin, phosphatidylethanolamineDerakhshandeh KHemati Azandaryani AKashanian SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2393-2401 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Derakhshandeh K Hemati Azandaryani A Kashanian S New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
description	Soheila Kashanian1, Abbas Hemati Azandaryani1, Katayoun Derakhshandeh2,3 1School of Chemistry, Nanoscience and Nanotechnology Research Center and Sensor and Biosensor Research Center, Razi University, 2Department of Pharmaceutics, Kermanshah University of Medical Sciences, 3Nanoscience and Technology Research Center School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran Background: Solid lipid nanoparticles (SLNs) are colloidal carrier systems which provide controlled-release profiles for many substances. In this study, we prepared aqueous dispersions of lipid nanoparticles using a modified, pH-sensitive derivative of phosphatidylethanolamine. Methods: SLNs were prepared using polysorbate 80 as the surfactant and tripalmitin glyceride and N-glutaryl phosphatidylethanolamine as the lipid components. Particle size, polydispersity index, and zeta potential were examined by photon correlation spectroscopy. Morphological evaluation was performed using scanning electron microscopy, atomic force microscopy, and differential scanning calorimetry. Results: Photon correlation spectroscopy revealed a particle hydrodynamic diameter of 165.8 nm and zeta potential of &ndash;41.6.0 mV for the drug-loaded nanoparticles. Atomic force microscopy investigation showed the nanoparticles to be 50&ndash;600 nm in length and 66.5 nm in height. Differential scanning calorimetry indicated that the majority of SLNs possessed less ordered arrangements of crystals compared with corresponding bulk lipids, which is favorable for improving drug-loading capacity. Drug-loading capacity and drug entrapment efficiency values for the SLNs were 25.32% and 94.32%, respectively. Conclusion: The SLNs prepared in this study were able to control the release of triamcinolone acetonide under acidic conditions. Keywords: solid lipid nanoparticles, high-shear homogenization, triamcinolone acetonide, tripalmitin, phosphatidylethanolamine
format	article
author	Derakhshandeh K Hemati Azandaryani A Kashanian S
author_facet	Derakhshandeh K Hemati Azandaryani A Kashanian S
author_sort	Derakhshandeh K
title	New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
title_short	New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
title_full	New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
title_fullStr	New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
title_full_unstemmed	New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
title_sort	new surface-modified solid lipid nanoparticles using n-glutaryl phosphatidylethanolamine as the outer shell
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/7c3e0ee26491484eb89e24d32c9b798a
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New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell

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