Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism

Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism

Cardiac hypertrophy is caused by cardiac volume or pressure overload conditions and ultimately leads to contractile dysfunction and heart failure. Oxytocin (OT), an endocrine nonapeptide, has been identified as a cardiovascular homeostatic hormone with anti-hypertrophic effects. However, the underly...

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Detalles Bibliográficos
Autores principales: Yuqiao Yang, Zhuoran Wang, Mengran Yao, Wei Xiong, Jun Wang, Yu Fang, Wei Yang, Haixia Jiang, Ning Song, Lan Liu, Jinqiao Qian
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
oxytocin
cardiac hypertrophy
lncRNA GAS5
miR-375-3p
KLF4
PI3K/AKT
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/7c3f8722a16547729211bc88cdc3f540
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