Dual-Specificity Phosphatases and Kidney Diseases

Background: Dual-specificity phosphatases (DUSPs) belong to the family of protein tyrosine phosphatases, which can dephosphorylate both serine/threonine and tyrosine residues. During the past decades, DUSPs have been implicated in various physiological and pathological activities. Besides mitogen-ac...

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Autores principales:	Haiyang Li, Jiachuan Xiong, Yu Du, Yinghui Huang, Jinghong Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	dual-specificity phosphatases dephosphorylate mitogen-activated protein kinases kidney diseases Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/7c3ffb04f52a4a27a7e5ac0931fe85a7
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spelling	oai:doaj.org-article:7c3ffb04f52a4a27a7e5ac0931fe85a72021-12-02T12:40:23ZDual-Specificity Phosphatases and Kidney Diseases2296-93812296-935710.1159/000520142https://doaj.org/article/7c3ffb04f52a4a27a7e5ac0931fe85a72021-12-01T00:00:00Zhttps://www.karger.com/Article/FullText/520142https://doaj.org/toc/2296-9381https://doaj.org/toc/2296-9357Background: Dual-specificity phosphatases (DUSPs) belong to the family of protein tyrosine phosphatases, which can dephosphorylate both serine/threonine and tyrosine residues. During the past decades, DUSPs have been implicated in various physiological and pathological activities. Besides mitogen-activated protein kinases (MAPKs) as the main substrates, other protein and nonprotein substrates can also be dephosphorylated by DUSPs. Aberrant regulations of DUSPs have been found in various diseases such as cancer, neurological disorders, and kidney diseases, suggesting the involvement of DUSPs in the pathogenesis of diseases. Summary: In this review, we summarize the general characteristics of DUSPs and the research progress made in the field of kidney diseases, including diabetic nephropathy, hypertensive nephropathy, chronic kidney disease, acute kidney injury, and lupus nephritis. As the main biochemical function of DUSPs is to dephosphorylate MAPKs activity, decreased DUSPs are found in kidney disease models, whereas forced DUSPs expression reverses the disease presentation, which was proved by using transgenic or gene knockout model. Key Messages: Mounting evidence demonstrates that DUSPs have essential physiological and pathological functions in kidney disease. Fully understanding the functions and mechanisms of DUSPs in kidney disease contributes to their clinical application in translation medicine.Haiyang LiJiachuan XiongYu DuYinghui HuangJinghong ZhaoKarger Publishersarticledual-specificity phosphatasesdephosphorylatemitogen-activated protein kinaseskidney diseasesInternal medicineRC31-1245ENKidney Diseases, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dual-specificity phosphatases dephosphorylate mitogen-activated protein kinases kidney diseases Internal medicine RC31-1245
spellingShingle	dual-specificity phosphatases dephosphorylate mitogen-activated protein kinases kidney diseases Internal medicine RC31-1245 Haiyang Li Jiachuan Xiong Yu Du Yinghui Huang Jinghong Zhao Dual-Specificity Phosphatases and Kidney Diseases
description	Background: Dual-specificity phosphatases (DUSPs) belong to the family of protein tyrosine phosphatases, which can dephosphorylate both serine/threonine and tyrosine residues. During the past decades, DUSPs have been implicated in various physiological and pathological activities. Besides mitogen-activated protein kinases (MAPKs) as the main substrates, other protein and nonprotein substrates can also be dephosphorylated by DUSPs. Aberrant regulations of DUSPs have been found in various diseases such as cancer, neurological disorders, and kidney diseases, suggesting the involvement of DUSPs in the pathogenesis of diseases. Summary: In this review, we summarize the general characteristics of DUSPs and the research progress made in the field of kidney diseases, including diabetic nephropathy, hypertensive nephropathy, chronic kidney disease, acute kidney injury, and lupus nephritis. As the main biochemical function of DUSPs is to dephosphorylate MAPKs activity, decreased DUSPs are found in kidney disease models, whereas forced DUSPs expression reverses the disease presentation, which was proved by using transgenic or gene knockout model. Key Messages: Mounting evidence demonstrates that DUSPs have essential physiological and pathological functions in kidney disease. Fully understanding the functions and mechanisms of DUSPs in kidney disease contributes to their clinical application in translation medicine.
format	article
author	Haiyang Li Jiachuan Xiong Yu Du Yinghui Huang Jinghong Zhao
author_facet	Haiyang Li Jiachuan Xiong Yu Du Yinghui Huang Jinghong Zhao
author_sort	Haiyang Li
title	Dual-Specificity Phosphatases and Kidney Diseases
title_short	Dual-Specificity Phosphatases and Kidney Diseases
title_full	Dual-Specificity Phosphatases and Kidney Diseases
title_fullStr	Dual-Specificity Phosphatases and Kidney Diseases
title_full_unstemmed	Dual-Specificity Phosphatases and Kidney Diseases
title_sort	dual-specificity phosphatases and kidney diseases
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/7c3ffb04f52a4a27a7e5ac0931fe85a7
work_keys_str_mv	AT haiyangli dualspecificityphosphatasesandkidneydiseases AT jiachuanxiong dualspecificityphosphatasesandkidneydiseases AT yudu dualspecificityphosphatasesandkidneydiseases AT yinghuihuang dualspecificityphosphatasesandkidneydiseases AT jinghongzhao dualspecificityphosphatasesandkidneydiseases
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Dual-Specificity Phosphatases and Kidney Diseases

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