A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging

D-luciferin is the standard bioluminescent substrate for in vitro and in vivo imaging. Here the authors introduce AkaLumine-HCl, a soluble luciferin analogue with a near-infrared emission maximum, which allows deep tissue imaging at lower concentrations than D-luciferin.

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Autores principales: Takahiro Kuchimaru, Satoshi Iwano, Masahiro Kiyama, Shun Mitsumata, Tetsuya Kadonosono, Haruki Niwa, Shojiro Maki, Shinae Kizaka-Kondoh
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/7c43d0c3cba6406684f84f686df358a9
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spelling oai:doaj.org-article:7c43d0c3cba6406684f84f686df358a92021-12-02T16:49:59ZA luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging10.1038/ncomms118562041-1723https://doaj.org/article/7c43d0c3cba6406684f84f686df358a92016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11856https://doaj.org/toc/2041-1723D-luciferin is the standard bioluminescent substrate for in vitro and in vivo imaging. Here the authors introduce AkaLumine-HCl, a soluble luciferin analogue with a near-infrared emission maximum, which allows deep tissue imaging at lower concentrations than D-luciferin.Takahiro KuchimaruSatoshi IwanoMasahiro KiyamaShun MitsumataTetsuya KadonosonoHaruki NiwaShojiro MakiShinae Kizaka-KondohNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Takahiro Kuchimaru
Satoshi Iwano
Masahiro Kiyama
Shun Mitsumata
Tetsuya Kadonosono
Haruki Niwa
Shojiro Maki
Shinae Kizaka-Kondoh
A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
description D-luciferin is the standard bioluminescent substrate for in vitro and in vivo imaging. Here the authors introduce AkaLumine-HCl, a soluble luciferin analogue with a near-infrared emission maximum, which allows deep tissue imaging at lower concentrations than D-luciferin.
format article
author Takahiro Kuchimaru
Satoshi Iwano
Masahiro Kiyama
Shun Mitsumata
Tetsuya Kadonosono
Haruki Niwa
Shojiro Maki
Shinae Kizaka-Kondoh
author_facet Takahiro Kuchimaru
Satoshi Iwano
Masahiro Kiyama
Shun Mitsumata
Tetsuya Kadonosono
Haruki Niwa
Shojiro Maki
Shinae Kizaka-Kondoh
author_sort Takahiro Kuchimaru
title A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
title_short A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
title_full A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
title_fullStr A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
title_full_unstemmed A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
title_sort luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/7c43d0c3cba6406684f84f686df358a9
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