ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS

Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search...

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Autores principales:	Diana M. MÁRQUEZ F., Alejandro MARTÍNEZ M.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Marine sponges Dyctioceratidae Ircinia epidioxysterols degradation products Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/7c43e2224c0d4019909a2e3dbe100931
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spelling	oai:doaj.org-article:7c43e2224c0d4019909a2e3dbe1009312021-11-19T04:21:30ZANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS0121-40042145-2660https://doaj.org/article/7c43e2224c0d4019909a2e3dbe1009312009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/587https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search for antiparasitic metabolites from marine sponges, we found that the Colombian Caribbean sponge Ircinia campana contains a complex mixture of epidioxysterols which displayed antileishmanial activity. This paper demonstrates that epidioxysterols found in this sponge are photo-oxidation products from the naturally occurring Δ5,7 sterols. These results suggest that epidioxysterols reported previously in sponges of the genus Ircinia are not naturally occurring products, so they are not valid chemotaxonomic markers for the sponges of this genus. Diana M. MÁRQUEZ F.Alejandro MARTÍNEZ M.Universidad de AntioquiaarticleMarine spongesDyctioceratidaeIrciniaepidioxysterolsdegradation productsFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Marine sponges Dyctioceratidae Ircinia epidioxysterols degradation products Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Marine sponges Dyctioceratidae Ircinia epidioxysterols degradation products Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diana M. MÁRQUEZ F. Alejandro MARTÍNEZ M. ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS
description	Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search for antiparasitic metabolites from marine sponges, we found that the Colombian Caribbean sponge Ircinia campana contains a complex mixture of epidioxysterols which displayed antileishmanial activity. This paper demonstrates that epidioxysterols found in this sponge are photo-oxidation products from the naturally occurring Δ5,7 sterols. These results suggest that epidioxysterols reported previously in sponges of the genus Ircinia are not naturally occurring products, so they are not valid chemotaxonomic markers for the sponges of this genus.
format	article
author	Diana M. MÁRQUEZ F. Alejandro MARTÍNEZ M.
author_facet	Diana M. MÁRQUEZ F. Alejandro MARTÍNEZ M.
author_sort	Diana M. MÁRQUEZ F.
title	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS
title_short	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS
title_full	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS
title_fullStr	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS
title_full_unstemmed	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS
title_sort	antileishmanial epidioxysterols from the colombian marine sponge <i>ircinia campana</i> are oxidation products from naturally occurring δ<sup>5,7</sup> sterols
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/7c43e2224c0d4019909a2e3dbe100931
work_keys_str_mv	AT dianammarquezf antileishmanialepidioxysterolsfromthecolombianmarinespongeiirciniacampanaiareoxidationproductsfromnaturallyoccurringdsup57supsterols AT alejandromartinezm antileishmanialepidioxysterolsfromthecolombianmarinespongeiirciniacampanaiareoxidationproductsfromnaturallyoccurringdsup57supsterols
_version_	1718420429272514560

ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE <I>Ircinia campana</I> ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ<sup>5,7</sup> STEROLS

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