Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples

Abstract The prevalence of HPV infection and its relationship with other sexually transmitted infections was analyzed in a cohort of 117 male partners of infertile couples from Cordoba, Argentina. Semen samples and urethral swabs were obtained and the infection with HPV, Chlamydia trachomatis, HSV1,...

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Autores principales:	Carolina Olivera, Jessica P. Mosmann, Daniela A. Paira, Rosa I. Molina, Andrea D. Tissera, Rubén D. Motrich, Cecilia G. Cuffini, Virginia E. Rivero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c468ffb1a73470e9e3a4a7570d8bf9d
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spelling	oai:doaj.org-article:7c468ffb1a73470e9e3a4a7570d8bf9d2021-12-02T17:13:22ZAssociation between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples10.1038/s41598-021-99279-92045-2322https://doaj.org/article/7c468ffb1a73470e9e3a4a7570d8bf9d2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99279-9https://doaj.org/toc/2045-2322Abstract The prevalence of HPV infection and its relationship with other sexually transmitted infections was analyzed in a cohort of 117 male partners of infertile couples from Cordoba, Argentina. Semen samples and urethral swabs were obtained and the infection with HPV, Chlamydia trachomatis, HSV1, HSV2, Mycoplasma hominis and Ureaplasma urealyticum was analyzed. A prevalence of HPV infection of 27.4% was found. Interestingly, infections by exclusively low risk HPV genotypes or high/intermediate risk HPV genotypes were present in 64.5% and 22.6% of cases, respectively. Low risk-HPV6 was the most frequently detected genotype. Remarkably, HPV and C. trachomatis infections were significantly associated to each other (OR: 11.55, 95% CI 1.14–117.06). No significant differences in sperm quality were found between HPV-positive and HPV-negative patients indicating that HPV male urogenital infection does not impair sperm quality. Our results show a high prevalence of HPV urogenital infection among male partners of infertile couples, and that HPV and C. trachomatis infections are reciprocal risk factors of their co-infection. Moreover, our results suggest that men constitute a reservoir for continued transmission of C. trachomatis and HPV to women highlighting the need for routine screening for these two pathogens in male partners of infertile couples.Carolina OliveraJessica P. MosmannDaniela A. PairaRosa I. MolinaAndrea D. TisseraRubén D. MotrichCecilia G. CuffiniVirginia E. RiveroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolina Olivera Jessica P. Mosmann Daniela A. Paira Rosa I. Molina Andrea D. Tissera Rubén D. Motrich Cecilia G. Cuffini Virginia E. Rivero Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples
description	Abstract The prevalence of HPV infection and its relationship with other sexually transmitted infections was analyzed in a cohort of 117 male partners of infertile couples from Cordoba, Argentina. Semen samples and urethral swabs were obtained and the infection with HPV, Chlamydia trachomatis, HSV1, HSV2, Mycoplasma hominis and Ureaplasma urealyticum was analyzed. A prevalence of HPV infection of 27.4% was found. Interestingly, infections by exclusively low risk HPV genotypes or high/intermediate risk HPV genotypes were present in 64.5% and 22.6% of cases, respectively. Low risk-HPV6 was the most frequently detected genotype. Remarkably, HPV and C. trachomatis infections were significantly associated to each other (OR: 11.55, 95% CI 1.14–117.06). No significant differences in sperm quality were found between HPV-positive and HPV-negative patients indicating that HPV male urogenital infection does not impair sperm quality. Our results show a high prevalence of HPV urogenital infection among male partners of infertile couples, and that HPV and C. trachomatis infections are reciprocal risk factors of their co-infection. Moreover, our results suggest that men constitute a reservoir for continued transmission of C. trachomatis and HPV to women highlighting the need for routine screening for these two pathogens in male partners of infertile couples.
format	article
author	Carolina Olivera Jessica P. Mosmann Daniela A. Paira Rosa I. Molina Andrea D. Tissera Rubén D. Motrich Cecilia G. Cuffini Virginia E. Rivero
author_facet	Carolina Olivera Jessica P. Mosmann Daniela A. Paira Rosa I. Molina Andrea D. Tissera Rubén D. Motrich Cecilia G. Cuffini Virginia E. Rivero
author_sort	Carolina Olivera
title	Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples
title_short	Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples
title_full	Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples
title_fullStr	Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples
title_full_unstemmed	Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples
title_sort	association between human papillomavirus and chlamydia trachomatis genital infections in male partners of infertile couples
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c468ffb1a73470e9e3a4a7570d8bf9d
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Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples

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