Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System

<i>Andrographis</i><i>paniculata</i> (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against vario...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sya’ban Putra Adiguna, Jonathan Ardhianto Panggabean, Akhirta Atikana, Febriana Untari, Fauzia Izzati, Asep Bayu, A’liyatur Rosyidah, Siti Irma Rahmawati, Masteria Yunovilsa Putra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Andrographis paniculata</i> andrographolide antivirals mechanism of action drug delivery system Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/7c487c3ffa904659a819f524e6db3d94
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c487c3ffa904659a819f524e6db3d94
record_format	dspace
spelling	oai:doaj.org-article:7c487c3ffa904659a819f524e6db3d942021-11-25T18:39:21ZAntiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System10.3390/ph141111021424-8247https://doaj.org/article/7c487c3ffa904659a819f524e6db3d942021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1102https://doaj.org/toc/1424-8247<i>Andrographis</i><i>paniculata</i> (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from <i>A. paniculata</i>, such as andrographolide and its analogs, have attracted much interest for their potential treatment against several virus infections, including SARS-CoV-2. The mechanisms of action in inhibiting viral infections can be categorized into several types, including regulating the viral entry stage, gene replication, and the formation of mature functional proteins. The efficacy of andrographolide as an antiviral candidate was further investigated since the phytoconstituents of <i>A. paniculata</i> exhibit various physicochemical characteristics, including low solubility and low bioavailability. A discussion on the delivery systems of these active compounds could accelerate their development for commercial applications as antiviral drugs. This study critically reviewed the current antiviral development based on andrographolide and its derivative compounds, especially on their mechanism of action as antiviral drugs and drug delivery systems.Sya’ban Putra AdigunaJonathan Ardhianto PanggabeanAkhirta AtikanaFebriana UntariFauzia IzzatiAsep BayuA’liyatur RosyidahSiti Irma RahmawatiMasteria Yunovilsa PutraMDPI AGarticle<i>Andrographis paniculata</i>andrographolideantiviralsmechanism of actiondrug delivery systemMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1102, p 1102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Andrographis paniculata</i> andrographolide antivirals mechanism of action drug delivery system Medicine R Pharmacy and materia medica RS1-441
spellingShingle	<i>Andrographis paniculata</i> andrographolide antivirals mechanism of action drug delivery system Medicine R Pharmacy and materia medica RS1-441 Sya’ban Putra Adiguna Jonathan Ardhianto Panggabean Akhirta Atikana Febriana Untari Fauzia Izzati Asep Bayu A’liyatur Rosyidah Siti Irma Rahmawati Masteria Yunovilsa Putra Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System
description	<i>Andrographis</i><i>paniculata</i> (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from <i>A. paniculata</i>, such as andrographolide and its analogs, have attracted much interest for their potential treatment against several virus infections, including SARS-CoV-2. The mechanisms of action in inhibiting viral infections can be categorized into several types, including regulating the viral entry stage, gene replication, and the formation of mature functional proteins. The efficacy of andrographolide as an antiviral candidate was further investigated since the phytoconstituents of <i>A. paniculata</i> exhibit various physicochemical characteristics, including low solubility and low bioavailability. A discussion on the delivery systems of these active compounds could accelerate their development for commercial applications as antiviral drugs. This study critically reviewed the current antiviral development based on andrographolide and its derivative compounds, especially on their mechanism of action as antiviral drugs and drug delivery systems.
format	article
author	Sya’ban Putra Adiguna Jonathan Ardhianto Panggabean Akhirta Atikana Febriana Untari Fauzia Izzati Asep Bayu A’liyatur Rosyidah Siti Irma Rahmawati Masteria Yunovilsa Putra
author_facet	Sya’ban Putra Adiguna Jonathan Ardhianto Panggabean Akhirta Atikana Febriana Untari Fauzia Izzati Asep Bayu A’liyatur Rosyidah Siti Irma Rahmawati Masteria Yunovilsa Putra
author_sort	Sya’ban Putra Adiguna
title	Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System
title_short	Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System
title_full	Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System
title_fullStr	Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System
title_full_unstemmed	Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System
title_sort	antiviral activities of andrographolide and its derivatives: mechanism of action and delivery system
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7c487c3ffa904659a819f524e6db3d94
work_keys_str_mv	AT syabanputraadiguna antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT jonathanardhiantopanggabean antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT akhirtaatikana antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT febrianauntari antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT fauziaizzati antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT asepbayu antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT aliyaturrosyidah antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT sitiirmarahmawati antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem AT masteriayunovilsaputra antiviralactivitiesofandrographolideanditsderivativesmechanismofactionanddeliverysystem
_version_	1718410844326330368

Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System

Ejemplares similares