Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive to angiotensin-mediated hypertension.

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Autores principales:	Xiaoping Liu, Mohamed A. El-Mahdy, James Boslett, Saradhadevi Varadharaj, Craig Hemann, Tamer M. Abdelghany, Raed S. Ismail, Sean C. Little, Danlei Zhou, Le Thi Thanh Thuy, Norifumi Kawada, Jay L. Zweier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c48b88ebe1f45628a4d604983c1bc11
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spelling	oai:doaj.org-article:7c48b88ebe1f45628a4d604983c1bc112021-12-02T17:06:12ZCytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall10.1038/ncomms148072041-1723https://doaj.org/article/7c48b88ebe1f45628a4d604983c1bc112017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14807https://doaj.org/toc/2041-1723The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive to angiotensin-mediated hypertension.Xiaoping LiuMohamed A. El-MahdyJames BoslettSaradhadevi VaradharajCraig HemannTamer M. AbdelghanyRaed S. IsmailSean C. LittleDanlei ZhouLe Thi Thanh ThuyNorifumi KawadaJay L. ZweierNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoping Liu Mohamed A. El-Mahdy James Boslett Saradhadevi Varadharaj Craig Hemann Tamer M. Abdelghany Raed S. Ismail Sean C. Little Danlei Zhou Le Thi Thanh Thuy Norifumi Kawada Jay L. Zweier Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
description	The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive to angiotensin-mediated hypertension.
format	article
author	Xiaoping Liu Mohamed A. El-Mahdy James Boslett Saradhadevi Varadharaj Craig Hemann Tamer M. Abdelghany Raed S. Ismail Sean C. Little Danlei Zhou Le Thi Thanh Thuy Norifumi Kawada Jay L. Zweier
author_facet	Xiaoping Liu Mohamed A. El-Mahdy James Boslett Saradhadevi Varadharaj Craig Hemann Tamer M. Abdelghany Raed S. Ismail Sean C. Little Danlei Zhou Le Thi Thanh Thuy Norifumi Kawada Jay L. Zweier
author_sort	Xiaoping Liu
title	Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
title_short	Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
title_full	Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
title_fullStr	Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
title_full_unstemmed	Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
title_sort	cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7c48b88ebe1f45628a4d604983c1bc11
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Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

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