Linked-read sequencing of gametes allows efficient genome-wide analysis of meiotic recombination

Linked-read sequencing of gametes allows efficient genome-wide analysis of meiotic recombination

Meiotic crossovers (COs) generate genetic variation and ensure proper chromosome segregation. Here, the authors develop a method for identifying COs at kilobase resolution in pooled recombinants using linked-read sequencing data, and apply it to investigate genome-wide CO landscapes of Arabidopsis t...

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Bibliographic Details
Main Authors: Hequan Sun, Beth A. Rowan, Pádraic J. Flood, Ronny Brandt, Janina Fuss, Angela M. Hancock, Richard W. Michelmore, Bruno Huettel, Korbinian Schneeberger
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/7c4b7b1beeff41c38b550e64c5ba8fad
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Summary:Meiotic crossovers (COs) generate genetic variation and ensure proper chromosome segregation. Here, the authors develop a method for identifying COs at kilobase resolution in pooled recombinants using linked-read sequencing data, and apply it to investigate genome-wide CO landscapes of Arabidopsis thaliana.

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