Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice

Abstract With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-ter...

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Autores principales:	Le Su, Yue Su, Zaiyong An, Ping Zhang, Qiulin Yue, Chen Zhao, Xin Sun, Song Zhang, Xinli Liu, Kunlun Li, Lin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7c4f73bbf760432ebcc479e5adc11147
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spelling	oai:doaj.org-article:7c4f73bbf760432ebcc479e5adc111472021-12-02T19:06:33ZFermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice10.1038/s41598-021-94594-72045-2322https://doaj.org/article/7c4f73bbf760432ebcc479e5adc111472021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94594-7https://doaj.org/toc/2045-2322Abstract With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-term used medicine for UC cure. Recently, the Chinese traditional herb Danshen has been investigated in the treatment of UC. However, it is a limitation of Danshen that many of the active components in Danshen are not easily absorbed by the human body. Probiotics could convert macromolecules into smaller molecules to facilitate absorption. Thus, Lactobacillus rhamnosus (F-B4-1) and Bacillus subtillis Natto (F-A7-1) were screened to ferment Danshen in this study. The fermented Danshen products were gavaged in the dextran sulfate sodium (DSS)-induced UC model mice. Danshen had better results to attenuate symptoms of DSS-induced UC after fermented with F-B4-1 and F-A7-1. Loss of body weight and disease activity index (DAI) were reduced. The abnormally short colon lengths and colonic damage were recovered. And fermented Danshen had the better inhibitory effect than Danshen itself on pro-inflammatory cytokine expression during DSS-induced UC. The results indicated that compared with Danshen, fermented Danshen relieved DSS-induced UC in mice more effectively. Danshen fermented by probiotics might be an effective treatment to UC in clinic stage in the future.Le SuYue SuZaiyong AnPing ZhangQiulin YueChen ZhaoXin SunSong ZhangXinli LiuKunlun LiLin ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Le Su Yue Su Zaiyong An Ping Zhang Qiulin Yue Chen Zhao Xin Sun Song Zhang Xinli Liu Kunlun Li Lin Zhao Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
description	Abstract With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-term used medicine for UC cure. Recently, the Chinese traditional herb Danshen has been investigated in the treatment of UC. However, it is a limitation of Danshen that many of the active components in Danshen are not easily absorbed by the human body. Probiotics could convert macromolecules into smaller molecules to facilitate absorption. Thus, Lactobacillus rhamnosus (F-B4-1) and Bacillus subtillis Natto (F-A7-1) were screened to ferment Danshen in this study. The fermented Danshen products were gavaged in the dextran sulfate sodium (DSS)-induced UC model mice. Danshen had better results to attenuate symptoms of DSS-induced UC after fermented with F-B4-1 and F-A7-1. Loss of body weight and disease activity index (DAI) were reduced. The abnormally short colon lengths and colonic damage were recovered. And fermented Danshen had the better inhibitory effect than Danshen itself on pro-inflammatory cytokine expression during DSS-induced UC. The results indicated that compared with Danshen, fermented Danshen relieved DSS-induced UC in mice more effectively. Danshen fermented by probiotics might be an effective treatment to UC in clinic stage in the future.
format	article
author	Le Su Yue Su Zaiyong An Ping Zhang Qiulin Yue Chen Zhao Xin Sun Song Zhang Xinli Liu Kunlun Li Lin Zhao
author_facet	Le Su Yue Su Zaiyong An Ping Zhang Qiulin Yue Chen Zhao Xin Sun Song Zhang Xinli Liu Kunlun Li Lin Zhao
author_sort	Le Su
title	Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
title_short	Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
title_full	Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
title_fullStr	Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
title_full_unstemmed	Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
title_sort	fermentation products of danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7c4f73bbf760432ebcc479e5adc11147
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Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice

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